Antipsychotic Agents

Drugs Injectable Form Equivalent Dose (mg) Daily Dosage (mg)a Sedation Incidence of Movement Disorders Anticholinergic Effects
Phenothiazines
Aliphatic
Chlorpromazine Yes 50 30-800 +++ ++ ++
Triflupromazine Yes 12.5 60-150 +++ ++ +++
Piperidine
Mesoridazine Yes 25 30-400 +++ + ++
Thioridazine No 50 150-800 +++ + +++
Piperazine
Acetophenazine No 10 60-120 ++ +++ ++
Fluphenazine Yes 1 1-40 + +++ +
Perphenazine Yes 4 12-64 + +++ ++
Prochlorperazine Yes 8 15-150 ++ +++ +
Trifluperazine Yes 2.5 2-40 + +++ +
Thioxanthenes
Chlorprothixene Yes 50 75-600 +++ ++ ++
Thiothixene Yes 2 8-30 + +++ +
Butyrophenone
Haloperidol Yes 1 1-15 + +++ +
Dihydroindolone
Molindone No 5 15-225 + +++ +
Dibenzoxazepine
Loxapine Yes 5 20-250 ++ +++ +
Diphenylbutylpiperidine
Pimozide No 2 1-25 ++ +++ ++
Dibenzodiazepine
Clozapine No Not available 100-90 + +

Note: +++ = high; ++ = moderate; + = low; — = not present.
a Dosages of oral medications only.

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