Category Archives: Depression

Managing at Work When You Are Depressed

My worst fear was that I would lose my job. I had missed more days of work in the last 2 months than I had in the last 2 years. Because of my sleep problems, I was tired and irritable all the time and I felt less productive. I was running behind in my paperwork… Read More »

Intimacy and Sex When You Are Depressed

I’ve always enjoyed my sex life, but recently it hasn’t been very satisfying for me or my partner. I just haven’t felt like making love. I feel so tired all the time that sex is the last thing on my mind. Even when I get aroused enough to want to have an intimate moment with… Read More »

Depression and Your Body

When the doctor first said “multiple sclerosis,” I felt so panicked that I really didn’t hear anything else she said that day. It felt like the end of the world. It wasn’t, but my world is different and it’s taken some work to adjust to it. I can’t always do the things I used to,… Read More »

Depression and Women’s Health

For many of us, our lives today seem busier than ever. The stresses and strains of work and family life demand much of our time and energy, and it often is difficult to make time for relaxation and enjoyment. For many women in particular, the tension between the demands of family and/or work roles and… Read More »

Personality and Treatment

Help-Seeking Behavior and Illness Detection Only a minority of people who have a diagnosable mental disorder receive professional help. This has been repeatedly shown across major epidemiological surveys (). In both the European Depression Epidemiological Survey (DEPRES) () and in the Ontario Health Survey (), fewer than 50% of detected cases of major depressive disorder… Read More »

Minor Depression

Etiology and Pathophysiology Minor depression is only a proposed diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and there are no International Classification of Diseases codes to categorize it. The proposed diagnostic category for minor depression in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition describes a depressive disorder that… Read More »

Minor Depression: Tricyclic Antidepressant

Tricyclic antidepressants entered the market in the 1960s after the Monoamine Oxidase Inhibitors but quickly lost their popularity when the selective serotonin reuptake inhibitors entered the market. Although tricyclic antidepressants are as effective as the selective serotonin reuptake inhibitors and serotonin/norepinephrine reuptake inhibitors in treating most forms of depression, they have the potential for cardiotoxicity… Read More »

Minor Depression: Bupropion

Dopaminergic/Noradrenergic Agents Bupropion (GSK’s Wellbutrin/Wellbutrin XR) acts on the noradren-ergic and dopaminergic system by inhibiting reuptake of norepinephrine and dopamine. Because bupropion does not affect the serotonergic system, this drug has become a common alternative or adjunct therapy for patients unable to bear the serotonergic side effects associated with serotonin reuptake inhibition (e.g., sedation, weight… Read More »

Minor Depression: Duloxetine, Venlafaxine, and Milnacipran

Serotonin-Norepinephrine Reuptake Inhibitors Several antidepressants have dual action at both serotonergic and noradrenergic receptors. The most notable are the serotonin/norepinephrine reuptake inhibitors, particularly extended-release venlafaxine (Wyeth’s Effexor XR) and milnacipran (bioMerieux-Pierre Fabre’s Ixel/Dalcipran, Asahi Kasei/Janssen-Kyowa’s Toledomin; available only in France and Japan). The noradrenergic and specific serotonergic antidepressants (NaSSAs) mirtazapine (Organon’s Remeron/Remergil), nefazodone (Bristol-Myers Squibb’s… Read More »