Category Archives: Side Effects of Drugs

Side Effects of Citalopram

Like the other SSRIs, citalopram is very well tolerated in general. It has a side effect profile markedly different from the older TCAs in that it is generally lacking significant anticholinergic effects. The most commonly reported adverse events (in comparison with placebo) include nausea (8% versus placebo), dry mouth (7.4%), somnolence (7.6%), increased sweating (3.9%),… Read More »

Side Effects of Paroxetine

When studying side effects, it is convenient to divide the body by systems. In this way, the repercussions of a drug acting on other bodily structures can be seen beyond cerebral parameters. Within this context, paroxetine affects every system. It affects the body as a whole primarily through asthenia (22%), the cardiovascular system with vasodilation… Read More »

Side Effects of Sertraline

For any chronic disorder, compliance is a key consideration in its long-term management, and the favorable tolerability profile of SSRIs compared with that of tricyclic antidepressants (TCAs) has been highlighted as a key advantage for the SSRIs (). Many patients are not prepared to tolerate the side effects associated with clomipramine, as illustrated by the… Read More »

Side Effects of Fluoxetine (Prozac)

Fluoxetine is well tolerated in most patients. Side effects that occurred significantly more with fluoxetine treatment than with placebo treatment were vasodilatation, dry mouth, nausea, decreased libido, somnolence, tremor, yawning, and sweating. There were relatively few discontinuations because of adverse events (approximately 10%) during the study by Tollefson et al. (1994). Applicable drugs: Prozac (fluoxetine)… Read More »

Side Effects of Clomipramine

Anafranil (clomipramine hydrochloride) is available as capsules of 25, 50, and 75 mg for oral administration. The side effects of clomipramine (trademarked as Anafranil and Clofranil) are typical of those seen with other TCAs. The literature disagrees on the relationship between side effects and plasma levels. Stern et al. (1980) found no relationship between side… Read More »

Side Effects Associated With Metabolic Adverse Events

Increased rates of obesity, T2DM, and cardiovascular disease in patients with bipolar disorder make it important for clinicians to distinguish between side effects that present tolerability issues (less severe, generally self-limited and manageable) and those that present more important safety issues that could contribute to medical morbidity and mortality. For example, increases in weight and… Read More »

Side Effects Of Antidepressants For Bipolar Disorder

Newer antidepressants have provided clinicians with treatment options that offer similar efficacy in comparison to tricyclic and heterocyclic antidepressants, with a more tolerable side effect profile. For example, these agents lack the cardiac toxicity potential of tricyclic antidepressants and are subsequently much less lethal in the event of overdose. While additional research remains to be… Read More »

Side Effects Of Antipsychotic Drugs Used For Bipolar Disorder

The use of antipsychotic medications for the treatment of mania was established many years ago using typical or first-generation antipsychotics. Recent evidence indicating effectiveness of second-generation agents for this indication, as well as for mixed states and possibly for relapse prevention using some agents, has increased the use of newer antipsychotics in the treatment of… Read More »

Side Effects Of Antiepileptic Drugs Used For Bipolar Disorder

Antiepileptic medications are being used increasingly in bipolar patients because of their potential mood-stabilizing properties. A large number of anticonvulsants are currently being evaluated for potential use in bipolar disorder, but evidence to date suggests that not all will be efficacious. Discussion will be restricted to the three agents with the greatest amount of positive… Read More »

Side Effects Of Lithium

Lithium continues to serve as the gold-standard mood stabilizer and a model for other agents being explored for their possible mood-stabilizing properties. Despite its narrow therapeutic index, lithium remains an important treatment for bipolar disorder. Adverse reactions to lithium that occur in >10% of patients include polydipsia, nausea, diarrhea, abnormal taste, and tremor. Less common… Read More »