Category Archives: Treatments for Mental Disorders

Treatment of late-onset mental disorder with antidepressants and neuroleptics

Drug treatment of late-life depression or schizophrenia is of great importance, as the functional psychoses are among the most common psychiatric diseases in the elderly. It therefore seems astonishing that there are great deficits in the drug research that has been done with this age group. There are almost no studies specifically on the treatment… Read More »

Drug treatment of elderly patients with depression

There is a consensus that antidepressant therapy is effective and should be recommended for the treatment of depression in the elderly. Because of the pharmacokinetic changes in the elderly, the tolerability of antidepressants, especially of the classic tricyclics, is reduced compared with younger populations. However, this problem can be managed by a careful dosing regime… Read More »

Neuroleptic treatment of schizophrenia in the elderly

Neuroleptics are commonly used to treat schizophrenia and also exogenic psychosis in elderly patients (). However, there are extremely few methodologically sound controlled trials of neuroleptic drugs in this population, especially of functional psychosis (). Clinical experience and case reports indicate that the efficacy proven in younger schizophrenic patients may be extrapolated to elderly psychotic… Read More »

Beta-Blockers in the Treatment of Social Phobia

The earliest pharmacological treatment of social phobia involved the use of beta-blockers in performers with stage fright. This is thought to be comparable to targeting a performance subtype of social phobia. The use of beta-blockers in the treatment of this type of social anxiety was intuitively based on the symptom profile of the disorder. Given… Read More »

Benzodiazepines in the Treatment of Social Phobia

Benzodiazepines, the most commonly used anxiolytic drugs in the treatment of chronic anxiety states, have also been investigated in the treatment of social phobia. These agents have been shown to be effective in the treatment of other anxiety disorders, including panic disorder and generalized anxiety disorder. Three benzodiazepines, all in the “high-potency” class of benzodiazepines… Read More »

Pharmacotherapy of Binge Eating Disorder

Pharmacotherapy versus placebo for binge eating disorder has been compared in five studies, and pharmacotherapy in combination with either cognitive-behavior therapy or behavioral weight loss has been tested in three studies. Overall, these first-generation pharmacotherapy trials have been of short duration, with short follow-ups, have used varied assessment methods, have operationalized binge eating disorder differently,… Read More »

Pharmacotherapy in the Treatment of Obesity

Until the 1990s, pharmacotherapy played a relatively minor role in the treatment of obesity. Available drugs were approved only for very short-term use. Difficulties in performing longer term studies, concerns regarding the safety and abuse of drugs, and consistent findings showing rapid weight regain following drug discontinuation contributed to the fact that no new obesity… Read More »

Pharmacotherapy in the Treatment of Substance Dependence

Common roles and indications for pharmacotherapy in the treatment of substance dependence disorders include the following. Detoxification For those classes of substances that produce substantial physical withdrawal syndromes (e.g., alcohol, opioids, sedative — hypnotics), drugs are often needed to reduce or control the often-dangerous symptoms associated with withdrawal. Benzodiazepenes are often used to manage symptoms… Read More »

Pharmacotherapy of Opioid Dependence

Methadone maintenance The inception of methadone maintenance treatment revolutionized the treatment of opioid addiction as it displayed the previously unseen ability to keep addicts in treatment and to reduce their illicit opioid use, outcomes with which nonpharmacological treatments had fared comparatively poorly. Beyond its ability to retain opioid addicts in treatment and help control opioid… Read More »

Pharmacotherapy of Alcohol Dependence

Disulfiram The most commonly used pharmacological adjunct for the treatment of alcohol dependence and abuse is disulfiram, or Antabuse. Disulfiram interferes with normal metabolism of alcohol, which results in an accumulation of acetaldhyde, and hence drinking following ingestion of disulfiram results in an intense physiologic reaction, characterized by flushing, rapid or irregular heartbeat, dizziness, nausea,… Read More »