Tag Archives: Amiodarone

Treatment of the epilepsy patient with hepatic disease

The liver is the principal organ of drug metabolism. Some drugs are absorbed from the gut, delivered to the liver and undergo first-pass metabolism prior to reaching the systemic circulation. Metabolism of these drugs is significantly affected by hepatic vascular supply; if hepatic blood flow is reduced, first-pass metabolism is decreased and more drug reaches… Read More »

Matching SSRI to Depressive Subtype

Atypical Depression Atypical depression is characterized by mood reactivity and two of the following: weight or appetite increase, hypersomnia, leaden paralysis and a pattern of interpersonal rejection sensitivity. MAOIs have been found to be superior to TCAs for atypical depression but recent views are that SSRIs are also an effective treatment for this subtype. Response… Read More »

Specific Conditions

Diabetes Tike dementia, non-insulin dependent diabetes mellitus is highly prevalent in elderly people. A number of studies have suggested that diabetes affects cognition, but the relationship with dementia has been uncertain. Increasingly it appears that diabetes is a risk factor, particularly for vascular dementia but also for Alzheimer’s disease. Interestingly, one study examining diabetes and… Read More »

Side Effects of Mood Stabilizers and Atypical Antipsychotics

This post provides an overview of developmental issues related to side effects, and then reviews the most common adverse events and concerns related to mood stabilizers and atypical antipsychotics. There are clear developmental differences in adverse event expression or side effects risks when mood stabilizers and antipsychotics are used in children and adolescents. All the… Read More »

Cataracts: Mostly Associated With Typical Antipsychotics

Drugs that are most frequently related to the development of lenticular changes include corticosteroids, phenothiazines, miotics, gold, amiodarone, and allo-purinol. Glaucoma and retinal detachment were the strongest predictors of cataracts. Diabetes mellitus increases the risk of cataracts fourfold. Overall antipsychotic drug use was not associated with cataracts. Risk is increased with the use of chlorpromazine… Read More »