Tag Archives: Amoxapine

Minor Depression: Tricyclic Antidepressant

Tricyclic antidepressants entered the market in the 1960s after the Monoamine Oxidase Inhibitors but quickly lost their popularity when the selective serotonin reuptake inhibitors entered the market. Although tricyclic antidepressants are as effective as the selective serotonin reuptake inhibitors and serotonin/norepinephrine reuptake inhibitors in treating most forms of depression, they have the potential for cardiotoxicity… Read More »

Minor Depression: Escitalopram, Paroxetine, Sertraline, and Fluoxetine

Selective Serotonin Reuptake Inhibitors The seven available agents in the selective serotonin reuptake inhibitor class are citalopram (Lund-beck’s Cipramil, Forest Laboratories’ Celexa, generics) and its single enan-tiomer, escitalopram (Lundbeck’s Cipralex, Forest’s Lexapro); paroxetine (GSK’s Paxil/Seroxat, Novartis’s Frosinor, generics); the controlled-release version of paroxetine (GSK’s Paxil CR); sertraline (Pfizer’s Zoloft); fluoxetine (Eli Lilly’s Prozac, generics); and… Read More »

Integrative Treatment of Depression and Comorbid Personality

The initial approach to patients with refractory or chronic depression begins with a comprehensive assessment of Axis I psychiatric disorders, including information from the patient as well as collateral sources. Unrecognized syndromal or subsyndromal psychiatric conditions (e.g., bipolar disorder, atypical depression, anxiety disorders, psychosis, substance abuse) may be found in some patients with chronic or… Read More »

Mood disorders: Intervention

As has been indicated, assessment of a primary mood disorder, especially depression, is difficult and involves exploration of many factors, since the mood disorder may be masked by physical problems and other mental disorders. Social workers are trained to look at all of the factors that are impinging on the individual, but they must be… Read More »

Antidepressant Drugs

Pharmacologic Profile General Use Used in the treatment of various forms of endogenous depression, often in conjunction with psychotherapy. Other uses include: Treatment of anxiety (doxepin, fluoxetine, paroxetine, sertraline, venlafaxine); Enuresis (imipramine); Chronic pain syndromes (amitriptyline, doxepin, imipramine, nortriptyline); Smoking cessation (bupropion); Bulimia (fluoxetine); Obsessive-compulsive disorder (fluoxetine, fluvoxamine, paroxetine, sertraline); Social anxiety disorder (paroxetine, sertraline).… Read More »

Treatment of Psychotic Depression

Substantial evidence supports the theory that psychotic depression represents a distinct type of major depression. Statistically significant differences between psychotic and nonpsychotic major depression have been noted along many axes, including presenting features, biology, familial transmission, course of illness, and response to treatment. Many centers have reported specific abnormalities on measures of hypothalamic-pituitary-adrenal axis activity… Read More »

Antidepressants in the Treatment of Psychotic Depression

Since the advent of tricyclic antidepressants in the late 1950s, it has been noted that psychotic major depression responds less robustly to tricyclic antidepressants alone than does nonpsychotic major depression. Angst noted that the presence of hypochondriacal delusions in 200 patients with depression that he studied predicted poor response to open-label treatment to 200 mg/day… Read More »

Antidepressant / Antipsychotic Combinations in the Treatment of Psychotic Depression

Although the data are fairly convincing that tricyclic antidepressants alone are not as efficacious in psychotic major depression as they are in nonpsychotic major depression, the data are equally convincing that combination therapy of a tricyclic antidepressant with an antipsychotic is an effective strategy for psychotic major depression. Several small, open-label studies have supported tricyclic… Read More »

Pharmacotherapy for Depression

Pharmacological treatments have gained popularity during the last 50 years as a method of treatment intervention for depression as well as for many other psychological disorders. They have been proven effective in ameliorating the symptoms for a large percentage of depressed individuals and are now the most common form of treatment for depression. The constraints… Read More »

Side Effects of Mood Stabilizers and Atypical Antipsychotics

This post provides an overview of developmental issues related to side effects, and then reviews the most common adverse events and concerns related to mood stabilizers and atypical antipsychotics. There are clear developmental differences in adverse event expression or side effects risks when mood stabilizers and antipsychotics are used in children and adolescents. All the… Read More »