Tag Archives: Ampalex

Schizophrenia: AMPA Receptor Modulators

Glutamate modulators for the treatment of schizophrenia have generated some interest because several lines of evidence support the idea that a weakened glutamatergic tone in the brains of schizophrenics upsets a balance between glutamatergic and dopaminergic transmission. This imbalance may then predispose schizophrenics to a risk of sensory overload and exaggerated responsiveness of the monoaminergic… Read More »

Schizophrenia: Serotonin-Dopamine Antagonists

Serotonin-dopamine antagonists, together with dopamine partial agonists, are considered atypical antipsychotics. serotonin-dopamine antagonists have been used for the treatment of schizophrenia since the early 1990s, and currently marketed serotonin-dopamine antagonists include Novartis’s clozapine (Clozaril/Leponex, generics), Janssen’s risperidone (Risperdal), Eli Lilly’s olanzapine (Zyprexa), AstraZeneca’s quetiapine (Seroquel), and Pfizer’s ziprasidone (Geodon/Zeldox). TABLE . Emerging Therapies in Development… Read More »