Tag Archives: Anafranil

Treating Anxiety Disorders In Adults

Anxiety is an emotional and physiological state that all people feel and that can be either normal or pathological. Anxiety can be defined as a feeling of unpleasant apprehension typically accompanied by bodily sensations such as a tightness in the chest, a feeling of choking, perspiring, and trembling or shaking. Often, anxious individuals feel restless… Read More »

Pharmacologic Treatment in Children and Adolescents for OCD

Clomipramine (Anafranil) Clomipramine (Anafranil), a tricyclic antidepressant (TCA) and potent serotonin re-uptake inhibitor, was used in the first controlled pharmacologic treatment trial in children and adolescents for OCD. Nineteen pediatric patients (mean age, 14.5 ± 2.3 years) were studied in a 12-week double-blind placebo-controlled crossover study (5 weeks of active medication) (). Doses of clomipramine… Read More »

Minor Depression: Tricyclic Antidepressant

Tricyclic antidepressants entered the market in the 1960s after the Monoamine Oxidase Inhibitors but quickly lost their popularity when the selective serotonin reuptake inhibitors entered the market. Although tricyclic antidepressants are as effective as the selective serotonin reuptake inhibitors and serotonin/norepinephrine reuptake inhibitors in treating most forms of depression, they have the potential for cardiotoxicity… Read More »

Minor Depression: Escitalopram, Paroxetine, Sertraline, and Fluoxetine

Selective Serotonin Reuptake Inhibitors The seven available agents in the selective serotonin reuptake inhibitor class are citalopram (Lund-beck’s Cipramil, Forest Laboratories’ Celexa, generics) and its single enan-tiomer, escitalopram (Lundbeck’s Cipralex, Forest’s Lexapro); paroxetine (GSK’s Paxil/Seroxat, Novartis’s Frosinor, generics); the controlled-release version of paroxetine (GSK’s Paxil CR); sertraline (Pfizer’s Zoloft); fluoxetine (Eli Lilly’s Prozac, generics); and… Read More »

Dissociative [Conversion] Disorders

Description of Medical Condition A sudden change in state of consciousness, identity, motor behavior, thoughts, feelings and perception of external reality to such an extent that these functions do not operate congruently. Many pathologic symptoms can be found, but the patient experiences dysphoria, suffering, and maladaptive functioning. Disorders include: • Dissociative amnesia • Dissociative fugue… Read More »

Autism

Description of Medical Condition Autism is a pervasive developmental disorder of early childhood characterized by severe impairment in: • Effective social skills • Absent or impaired language development • Repetitive and/or stereotyped activities and interests, especially inanimate objects System(s) affected: Nervous Genetics: High concordance in monozygotic twins; increased prevalence in siblings Incidence/Prevalence in USA: About… Read More »

Clomipramine: Treatment Duration and Discontinuation

Because of the considerable time lag that can exist (6-10 weeks) between initial dosing and onset of significant improvement, patients will need a lot of encouragement to remain compliant with their treatment regimen. Because side effects often appear before any clinical improvement, patients are prone to early discouragement with clomipramine. Often, simply talking with them… Read More »

Side Effects of Clomipramine

Anafranil (clomipramine hydrochloride) is available as capsules of 25, 50, and 75 mg for oral administration. The side effects of clomipramine (trademarked as Anafranil and Clofranil) are typical of those seen with other TCAs. The literature disagrees on the relationship between side effects and plasma levels. Stern et al. (1980) found no relationship between side… Read More »

Doses of Clomipramine for OCD

Prescribing clomipramine (trademarked as Anafranil and Clofranil) for patients with obsessive-compulsive disorder requires consideration of not only the nature of the drug but also the nature of the disorder. On the one hand, it has been our clinical experience that patients with obsessive-compulsive disorder are incredibly tolerant of side effects (see case examples at the… Read More »