Tag Archives: Arava

Mitoxantrone in Multiple Sclerosis

Mitoxantrone () was developed in the 1970s and is an antineoplastic agent. It is an anthracenedione derivative related to the anthracyclins doxorubicine and daunorubicine. It interacts with topoisomerase-2, stabilizes its cleavable complex with DNA, thus prevents the ligation of DNA strands, and consecutively delays the cell-cycle progression. Mitoxantrone is used to effectively treat malignancies such… Read More »

Special Considerations for Treatment of Restless Legs Syndrome

Side Effects of Dopaminergic Treatments Dopaminergic agents (dopamine agonists and levodopa) are usually considered first-line therapy in restless legs syndrome. Common side effects of dopamine agonists include nausea, dizziness, orthostatic hypotension, and headache (). A very slow dose titration will help minimize side effects. Hallucinations are another common side effects of dopaminergic therapy in Parkinson’s… Read More »

Chronic Headache & Steroids

Steroids: A. Have proven benefit in withdrawal therapy following medication overuse headache (MOH). B. Have proven benefit in prevention of headache relapse after acute migraine headaches. C. May cause aseptic osteonecrosis with short-term, intermittent pulse doses in migraine patients. D. Are contraindicated in acute vestibular neuritis. E. All of the above The answer is C.… Read More »