Tag Archives: Brofaromine

Treatments for Social Phobia

Social phobia was first described as a unique, diagnosable disorder in DSM-III (American Psychiatric Association 1980). From a historical perspective, the disorder has been recognized since the middle of the 19th century, when Casper described erythrophobia (Casper 1902). Marks (1970) separated social phobia from other types of anxiety, including agoraphobia and simple phobia; thus, he… Read More »

Drug treatment of elderly patients with depression

There is a consensus that antidepressant therapy is effective and should be recommended for the treatment of depression in the elderly. Because of the pharmacokinetic changes in the elderly, the tolerability of antidepressants, especially of the classic tricyclics, is reduced compared with younger populations. However, this problem can be managed by a careful dosing regime… Read More »

Treatment for Social Phobia

Management Effective pharmacological and psychological treatments of social phobia are available. At present, phenelzine is the pharmacological treatment of choice, and cognitive-behavioral group treatment is the psychological treatment of choice for the generalized subtype (). These treatments appear to be about equally effective and, when combined, may work better than either treatment alone. Evidence favoring… Read More »

Treatment for Panic Disorder and Agoraphobia

Medical management Effective treatment of panic disorder depends upon establishing and communicating the diagnosis. Initially, many patients are convinced that they are physically ill and resist the idea that their problem may be psychiatric (). Other patients reject the diagnosis of panic disorder because, for them, it implies weakness or responsibility for symptoms. Of course,… Read More »

Interpreting the Pharmacotherapy Literature in PTSD

The diverse presentation of symptoms in posttraumatic stress disorder and the number of neurobiological systems that may be affected present a challenge in the search for effective pharmacological agents in treatment. Very few controlled clinical studies in pharmacotherapy exist, although several medications have shown promise in both open trials and case reports. Table Controlled drug… Read More »

Review of Pharmacotherapy Literature in Posttraumatic Stress Disorder

Tricyclic Antidepressants Three placebo-controlled trials of traditional tricyclic antidepressants in chronic posttraumatic stress disorder have been published, all among male war veterans. The three drugs studied were desipramine, imipramine, and amitriptyline. The outcomes may reflect, in part, differences among these drugs and other factors such as length of trials, dosages, or symptom profiles. Desipramine was… Read More »

Reversible Inhibitors of Monoamine Oxidase-A

The use of standard nonreversible monoamine oxidase inhibitors is limited by their side effects, especially the risk of hypertensive crisis if dietary restrictions are not followed. This led to the development of the reversible inhibitors of MAO-A (RIMAs), which have a significantly lower ability to potentiate the pressor effect of tyramine. This allows for relaxation… Read More »

Medication Selection for Social Phobia

Until 1985, little was known about psychopharmacotherapy for social phobia. At present, evidence indicates that several drugs may be useful in the treatment of that disorder. Twenty double-blind, placebo-controlled studies have been published to date, evaluating 10 drugs (phenelzine = 4, brofaromine = 3, moclobemide = 4, clonazepam = 1, alprazolam = 1, atenolol =… Read More »

Pharmacotherapeutic Treatments for Panic Disorder

Selective Serotonin Reuptake Inhibitors The selective serotonin reuptake inhibitors have become the mainstay of pharmacological treatment for mood and anxiety disorders. Selective serotonin reuptake inhibitors were considered the first-line treatment by a group of experts in anxiety for years before controlled studies appeared, and a meta-analysis of the controlled studies up to 1995 that included… Read More »

Pharmacotherapy for Depression

Pharmacological treatments have gained popularity during the last 50 years as a method of treatment intervention for depression as well as for many other psychological disorders. They have been proven effective in ameliorating the symptoms for a large percentage of depressed individuals and are now the most common form of treatment for depression. The constraints… Read More »