Tag Archives: Buprenorphine

Pharmacological Treatment of Pain

While medications are often prescribed for all types of chronic pain, research has consistently shown that several classes have proven efficacy for the treatment of neuropathic pain. Ideally, pharmacotherapy of pain would be specifically selected on the basis of considerations of etiology (e.g., ischemic, neuropathic), pathophysiology (e.g., demyelination, central pain), and anatomy (e.g., C fibers,… Read More »

Opioids In Chronic Pain

The use of opioids in pain of non-malignant origin is controversial and depends on a proper understanding of the nature of chronic pain, and the strategy of its management. Patients with chronic pain who take opioids must understand the rationale for the use and be prepared to be an active partner in the management of… Read More »

Substance-Related Disorders: Intervention

The cocaine and crack epidemic of the 1980s challenged traditional alcohol and drug treatment programs, because it resulted in a significant number of people being addicted not only to cocaine or crack but also to alcohol. It pointed out the failure of a system that separates alcoholism and chemical dependency, and it increased the importance… Read More »

Opioid Analgesics

Pharmacologic Profile General Use Management of moderate to severe pain. Fentanyl is also used as a general anesthetic adjunct. General Action and Information Opioids bind to opiate receptors in the CNS, where they act as agonists of endogenously occurring opioid peptides (eukephalins and endorphins). The result is alteration to the perception of and response to… Read More »

Pharmacotherapy in the Treatment of Substance Dependence

Common roles and indications for pharmacotherapy in the treatment of substance dependence disorders include the following. Detoxification For those classes of substances that produce substantial physical withdrawal syndromes (e.g., alcohol, opioids, sedative — hypnotics), drugs are often needed to reduce or control the often-dangerous symptoms associated with withdrawal. Benzodiazepenes are often used to manage symptoms… Read More »

Pharmacotherapy of Opioid Dependence

Methadone maintenance The inception of methadone maintenance treatment revolutionized the treatment of opioid addiction as it displayed the previously unseen ability to keep addicts in treatment and to reduce their illicit opioid use, outcomes with which nonpharmacological treatments had fared comparatively poorly. Beyond its ability to retain opioid addicts in treatment and help control opioid… Read More »

Mood Stabilizing Medications in the Treatment of Psychotic Disorders

Mood Stabilizing Medications in the Treatment of Psychotic Disorders of Children and Adolescents, Other Treatments, and Alternative Treatments For a variety of reasons, other medications are added frequently to the psychopharmacological treatment of chronic psychotic conditions in children and adolescents. Among these, mood stabilizers (valproate, lithium, lamotrigene, and others) play a significant role in the… Read More »

Side Effects of Mood Stabilizers and Atypical Antipsychotics

This post provides an overview of developmental issues related to side effects, and then reviews the most common adverse events and concerns related to mood stabilizers and atypical antipsychotics. There are clear developmental differences in adverse event expression or side effects risks when mood stabilizers and antipsychotics are used in children and adolescents. All the… Read More »