Tag Archives: Butyrophenone

Drug Treatment Of Mania

When assessing the patient, enquiries should be made about their recent compliance with medication, as sudden discontinuation of lithium may have triggered the manic episode. It is usually prudent to cease any antidepressant medication they may have been taking. A physical examination and tests of the blood and urine should, if possible, precede drug treatment… Read More »

Pharmacotherapy in the Treatment of People With Schizophrenia

The pharmacological agents most primarily associated with treatment of schizophrenia are grouped in a large and heterogeneous family, the antipsychotics. Recently, this family has been subdivided into the typicals, or neuroleptics, and the atypicals (see Tables Selected Typical Antipsychotic Drugs and Their Characteristics and Atypical Antipsychotics: Relative Potencies and Side Effects). The neuroleptics are so… Read More »

Neuroleptic treatment of schizophrenia in the elderly

Neuroleptics are commonly used to treat schizophrenia and also exogenic psychosis in elderly patients (). However, there are extremely few methodologically sound controlled trials of neuroleptic drugs in this population, especially of functional psychosis (). Clinical experience and case reports indicate that the efficacy proven in younger schizophrenic patients may be extrapolated to elderly psychotic… Read More »

Drug-centred drug research

The disease-centred model of drug action has restricted our understanding of the effects of drugs used in psychiatry by directing attention to the effects of drugs on a hypothetical disease process and neglecting other areas. For example, although there is ample research about effects of the new generation of antipsychotic drugs on the numerous different… Read More »

Antipsychotic Drugs

Pharmacologic Profile General Use Treatment of acute and chronic psychoses, particularly when accompanied by increased psychomotor activity. Use of clozapine is limited to schizophrenia unresponsive to conventional therapy. Selected agents are also used as antihistamines or antiemetics. Chlorpromazine is also used in the treatment of intractable hiccups. General Action and Information Blockdopamine receptors in the… Read More »

Antipsychotics For The Treatment Of Schizophrenia

Following the Anatomical Therapeutic Chemical (ATC) classification system by WHO Collaborating Centre for Drug Statistics Methodology), antipsychotics (ATC N05A) are classified as: • N05AA Phenothiazines with aliphatic side-chain: Chlorpromazine, Levomepromazine, Promazine, Triflupromazine, Cyamemazine, Chlorproethazine • N05AB Phenothiazines with piperazine structure: Dixyrazine, Fluphenazine, Perphenazine, Prochlorperazine, Thiopropazate, Trifluoperazine, Acetophenazine, Thioproperazine, Butaperazine, Perazine • N05AC Phenothiazines with piperidine… Read More »

Typical Antipsychotics For The Treatment Of Schizophrenia

Lithium • Lithium and lithium salts (especially carbonate or citrate) were the focus of research in depression topic in the 1930’s. Lithium carbonate was launched in 1939 by Solvay for the treatment of depression and schizophrenia, and in 2002 Glaxo launched it for the treatment of mania • For many years, the effect of lithium… Read More »

Sudden Death

Rare, Potentially Predictable Epidemiological studies indicate that exposure to antipsychotic medications is associated with sudden death. The association is valid for current use, not for past use. Sudden cardiac risk was the highest among patients receiving butyrophenone antipsychotics, mainly pipamperone and haloperidol, even at low doses. Sudden cardiac death is associated with antipsychotic use rather… Read More »