Tag Archives: Chloramphenicol

Delirium: Etiology

Delirium has a wide variety of etiologies, which may occur alone or in combination (). These include primary cerebral disorders, systemic disturbances that affect cerebral function, drug and toxin exposure (including intoxication and withdrawal), and a range of factors that can contribute to delirium but have an uncertain role as etiological factors by themselves (psychological… Read More »

Principles of Antimicrobial Therapy

A governing principle in the treatment of infectious diseases is summarized by the aphorism “the right drug for the right bug,” a statement that is as complex as it is simple. This aphorism is particularly critical when considering infections involving the central nervous system (CNS) for two main reasons: (1) the blood-brain barrier (BBB) limits… Read More »

Pharmacodynamics Of Antimicrobial Agents In Bacterial Meningitis

Pharmacodynamics entails the interactions that occur between the antimicrobial agent and the pathogen, and, although separate from pharmacokinetic properties, is dependent on these processes with respect to localizing antimicrobials at sites of infection. There are several pharmacodynamic properties of antimicrobials relevant to bacterial meningitis, including bactericidal / bacteriostatic activity, time- versus concentration-dependent killing, and postantimicrobial… Read More »

Duration Of Antimicrobial Therapy For CNS Infections

Little information is available addressing the appropriate duration of therapy for most types of central nervous system infection. Some experimental and clinical data are available for the effective duration of bacterial meningitis, especially for meningitis caused by N. meningitidis. For nonmeningococcal meningitis, the recommended duration of therapy is 10-14 days, but this duration is based… Read More »