Tag Archives: Clobazam

Treatment Of Childhood Absence Epilepsy: American Academy Of Neurology Guidelines

New Anti-Epileptic Drugs Only American Academy of Neurology (AAN) guidelines evaluating efficacy of new anti-epileptic drugs state only that lamotrigine is effective in children with newly diagnosed absence seizures (level B recommendation). Ethosuximide After ethosuximide was described as effective in absence epilepsy in 1958, a number of open-label, non-comparative studies where ethosuximide was added to… Read More »

Treatment Of The Child Or Adolescent With Newly Diagnosed Epilepsy

Paediatric epilepsy is amazingly diverse. In some children, basic diagnosis, seizure classification and treatment are straightforward. Other patients have difficult-to-diagnose seizures, complicated seizure classification and a variable response to treatment. Some seizures are subclinical, others are barely noticeable, and occasionally they are life threatening. Many children with epilepsy have no associated disabilities, but all children… Read More »

Outgrowing Epilepsy in Children

Slightly more than half of the children who have epilepsy outgrow it. This simple and positive fact raises important questions: Which children should be treated? How much medication should they receive? How long should antiepileptic drugs be used? Doctors’ views on antiepileptic drugs have changed. Several decades ago, many doctors believed that seizures must be… Read More »


Alprazolam • The compound was patented in 1969 by Upjohn Co. • First launched by Pfizer in 1983 for the treatment of anxiety • Approval in the USA for the treatment of panic disorder with or without agoraphobia in 2003 Clonazepam • First described in 1963 as sedative, muscle relaxant and anticonvulsant • Parenteral formulation… Read More »

Drugs Used to Treat Epilepsy

Drug selection is a complicated clinical decision, influenced by data from controlled trials, the doctor’s experience and bias, and the patient and family input. Factors that should be considered include the seizure type and epilepsy syndrome, likely effectiveness and possible side effects, cost, how often it must be taken, and interactions. This chapter reviews the… Read More »

Drugs Commonly Used Against Epilepsy

The following pages discuss the most commonly used antiepileptic drugs, listed alphabetically. A discussion of the role of benzodiazepines (clonazepam, clobazam, clorazepate, diazepam, lorazepam) follows. Acetazolamide Acetazolamide (Diamox ®) can be used with another drug to treat absence and myoclonic seizures. It is also used to treat partial or generalized seizures that occur more often… Read More »

The Role of Benzodiazepines in Treating Epilepsy

  Benzodiazepines (clonazepam, clobazam, clorazepate, diazepam, lorazepam) are effective as short-term therapy to help prevent or stop generalized and partial seizures. They are also used to treat anxiety. Tolerance often develops within weeks, however, so that the same dose of medication has less effect, whether for epilepsy or anxiety. Benzodiazepines are very commonly used to… Read More »

Principles of Drug Therapy for Epilepsy

Antiepileptic drugs (AEDs) are the principal therapy for epilepsy. Choosing an effective drug depends on correctly diagnosing the type of epilepsy (generalized versus partial) and, ideally, the epilepsy syndrome. Next, a decision whether or not to treat needs to be made. For most patients, the benefits of antiepileptic drugs and seizure control outweigh the risks.… Read More »

Adverse Effects of Antiepileptic Drugs

Doctors and patients with epilepsy see medical care from different perspectives. The doctor would like to see the patient regularly, have the patient take medication regularly, and have the patient’s seizures well controlled. The patient would like never to see a doctor, never to take a pill, and have the seizures go away. Patients often… Read More »