Tag Archives: Clozapine

Pharmacological Treatment of Dementia

General guidelines for psychotropic medication use in frail elderly patients are applicable. Systematic evidence to support the effectiveness of particular psychotropic drugs in dementia patients is limited. Therefore, choice of drug class may be based on clinical evidence, and choice of agent is often based on the side-effect profile and on the characteristics of a… Read More »

Management of Bipolar Disorder

Antipsychotics are frequently used in the treatment of bipolar disorder. Most patients started on antipsychotics as adjunctive treatment for manic episodes continue these agents beyond 6 months, even in the absence of conclusive data on the long-term efficacy of most antipsychotics in maintenance treatment. Typical antipsychotics are effective antimanic agents but appear less effective than… Read More »

Combining of two psychotropic agents

Question. My question involves the combining of two psychotropic agents. I am unclear why it is done and why it works. I treat chronically ill patients, mostly with schizophrenia or schizoaffective disorder. They are treated with agents that functionally decrease dopamine, i.e. Haldol, Clozaril etc. If they become depressed, and the depression does not respond… Read More »

Caffeine and Psychotropics

Question. Are there any psychotropics that have a negative interaction with caffeine? Is caffeine bad for people with certain disorders? Answer. There are certainly psychotropics that can interact with caffeine in clinically important ways, though not always in bad ways. First, though, it’s important to distinguish two types of drug-drug interactions. In one type of… Read More »

Schizophrenia-Negative Mode

Question. What is going on inside the mind of an adult currently suffering from schizophrenia-negative mode? Answer. It is always hard to know what is truly “going on inside the mind” of any patient, particularly patients with psychotic disorders. I am also not quite sure what you mean by “schizophrenia-negative mode,” but I assume you… Read More »

When to Introduce Antipsychotics

Question. When do you feel antipsychotics should be used to treat anxiety? My patient is very distressed, cannot concentrate and has a hard time with rational thought. He suggested this as a possible option, but what do you think? Answer. Unless the anxiety is really secondary to a psychotic process, I would argue that the… Read More »

Treatment for Late-Onset Schizophrenia

As with other types or forms of schizophrenia, neuroleptic or anti-psychotic drugs constitute the mainstay of treatment for late-onset schizophrenia. Conventional or typical neuroleptics Clinical experience and anecdotal reports suggest that neuroleptic therapy produces a positive outcome (remission or reduction in symptoms, and earlier discharge from hospital) in a majority of older patients with schizophrenia… Read More »

Schizophrenia: Current Therapies

Etiology and Pathophysiology Schizophrenia has varied and ominous symptoms that generally begin in late adolescence or early adulthood and usually continue throughout life. The diagnostic criteria for schizophrenia have evolved over the past 20 years based on the different iterations of the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases.… Read More »

Schizophrenia: Atypical Antipsychotics

Many atypical antipsychotics are available. In addition to those reviewed in the following sections, atypical agents include perospirone (Sumitomo’s Lullan) and zotepine (Fujisawa’s Lodopin, Aventis’s Nipolept, Orion Pharma’ s Zoleptil, generics). These drugs are not discussed in detail here because their mechanisms of action are similar to those of other atypical agents, they are launched… Read More »