Tag Archives: Clozaril

Combining of two psychotropic agents

Question. My question involves the combining of two psychotropic agents. I am unclear why it is done and why it works. I treat chronically ill patients, mostly with schizophrenia or schizoaffective disorder. They are treated with agents that functionally decrease dopamine, i.e. Haldol, Clozaril etc. If they become depressed, and the depression does not respond… Read More »

When to Introduce Antipsychotics

Question. When do you feel antipsychotics should be used to treat anxiety? My patient is very distressed, cannot concentrate and has a hard time with rational thought. He suggested this as a possible option, but what do you think? Answer. Unless the anxiety is really secondary to a psychotic process, I would argue that the… Read More »

Schizophrenia: Current Therapies

Etiology and Pathophysiology Schizophrenia has varied and ominous symptoms that generally begin in late adolescence or early adulthood and usually continue throughout life. The diagnostic criteria for schizophrenia have evolved over the past 20 years based on the different iterations of the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases.… Read More »

Schizophrenia: Atypical Antipsychotics

Many atypical antipsychotics are available. In addition to those reviewed in the following sections, atypical agents include perospirone (Sumitomo’s Lullan) and zotepine (Fujisawa’s Lodopin, Aventis’s Nipolept, Orion Pharma’ s Zoleptil, generics). These drugs are not discussed in detail here because their mechanisms of action are similar to those of other atypical agents, they are launched… Read More »

Schizophrenia: Serotonin-Dopamine Antagonists

Serotonin-dopamine antagonists, together with dopamine partial agonists, are considered atypical antipsychotics. serotonin-dopamine antagonists have been used for the treatment of schizophrenia since the early 1990s, and currently marketed serotonin-dopamine antagonists include Novartis’s clozapine (Clozaril/Leponex, generics), Janssen’s risperidone (Risperdal), Eli Lilly’s olanzapine (Zyprexa), AstraZeneca’s quetiapine (Seroquel), and Pfizer’s ziprasidone (Geodon/Zeldox). TABLE . Emerging Therapies in Development… Read More »

Changing Views of Schizophrenia and Antipsychotic Agents

In the years following the introduction of the first antipsychotic drugs (the mid-1950s), their most clinically salient effect was suppression of the symptoms of acute psychosis, including delusions, hallucinations, thought disorder, agitation, and gross disorganization. The past several years of research on the outcome of pharmacotherapy for schizophrenia have seen an emphasis on the domains… Read More »

Personality Disorders

Description of Medical Condition A group of conditions, with onset at or before adolescence, characterized by enduring patterns of maladaptive and dysfunctional behavior that deviate markedly from one’s culture and social environment leading to functional impairment and distress to the individual, coworkers and the family. These behaviors are perceived by the patient to be “normal”… Read More »

Chronic Illness: Current Therapies

The main goal of bipolar disorder drug treatment is to establish euthymia (stable mood with a persistent sense of well-being) without inducing mania or rapid cycling (i.e., four or more mood episodes in a 12-month period). For this reason, drug treatment usually consists of an agent or, more frequently, combinations of agents that exert both… Read More »

Antipsychotic Drug Clozapine (Clozaril)

Information About Antipsychotic Drug Clozapine (Clozaril) for Patients and Families Clozapine (Clozaril) was used in Europe for many decades before it become available in the United States in 1989. Clozapine is one of the earlier second-generation antipsychotics that represent a new class of medicines with actions uniquely different from those of the older, first-generation antipsychotics.… Read More »