Tag Archives: Cycloserine

Pharmacological Treatment of Dementia

General guidelines for psychotropic medication use in frail elderly patients are applicable. Systematic evidence to support the effectiveness of particular psychotropic drugs in dementia patients is limited. Therefore, choice of drug class may be based on clinical evidence, and choice of agent is often based on the side-effect profile and on the characteristics of a… Read More »

Schizophrenia: Current Therapies

Etiology and Pathophysiology Schizophrenia has varied and ominous symptoms that generally begin in late adolescence or early adulthood and usually continue throughout life. The diagnostic criteria for schizophrenia have evolved over the past 20 years based on the different iterations of the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases.… Read More »

Schizophrenia: Serotonin-Dopamine Antagonists

Serotonin-dopamine antagonists, together with dopamine partial agonists, are considered atypical antipsychotics. serotonin-dopamine antagonists have been used for the treatment of schizophrenia since the early 1990s, and currently marketed serotonin-dopamine antagonists include Novartis’s clozapine (Clozaril/Leponex, generics), Janssen’s risperidone (Risperdal), Eli Lilly’s olanzapine (Zyprexa), AstraZeneca’s quetiapine (Seroquel), and Pfizer’s ziprasidone (Geodon/Zeldox). TABLE . Emerging Therapies in Development… Read More »

Schizophrenia: Other Pharmacological Treatments

Because antipsychotic medications often fail to resolve the full range of schizophrenic psychopathology and other common symptoms (e.g., anxiety, depression, mood instability, motor unrest), adjunctive treatments are commonly tried. Adjunctive pharmacological treatments in patients with schizophrenia have been the subject of numerous reviews (). In addition, some psychotropic medications other than antipsychotics have been used… Read More »

Mild to Moderate Alzheimer’s Disease

Mild to moderate Alzheimer’s disease (AD) is that disease stage where cognitive, functional and increasingly the behavioural symptoms affect everyday life. By this stage the diagnosis can generally be made clinically with considerable confidence. Although biological markers that are in development may help diagnostically in the future, they still have not found their way into… Read More »

Principles of management

The management of major depressive disorder (major depressive disorder) involves establishing a correct diagnosis and applying evidence based and goal directed principles of treatment. These treatment principles include recognizing and treating any coexisting medical conditions, building a therapeutic alliance with patients and choosing an appropriate treatment, as well as monitoring and maintaining response (Table Nine… Read More »