Tag Archives: Depakene

Chronic Illness: Current Therapies

The main goal of bipolar disorder drug treatment is to establish euthymia (stable mood with a persistent sense of well-being) without inducing mania or rapid cycling (i.e., four or more mood episodes in a 12-month period). For this reason, drug treatment usually consists of an agent or, more frequently, combinations of agents that exert both… Read More »

Treatment Of The Child Or Adolescent With Newly Diagnosed Epilepsy

Paediatric epilepsy is amazingly diverse. In some children, basic diagnosis, seizure classification and treatment are straightforward. Other patients have difficult-to-diagnose seizures, complicated seizure classification and a variable response to treatment. Some seizures are subclinical, others are barely noticeable, and occasionally they are life threatening. Many children with epilepsy have no associated disabilities, but all children… Read More »

Which of the drugs appears to be the most effective preventative drug for children and adolescents with headaches?

Which of the following appears to be the most effective preventative medication for children and adolescents with migraine headaches? A. Propranolol (Inderal) B. Gabapentin (Neurontin) C. Topiramate (Topamax) D. Levetiracetam (Keppra) E. Zonisamide (Zonegran) The answer is C. Data on preventative medication for children and adolescents with migraine headaches is sparse, as noted by the… Read More »

Which drug increases the half-life of lamotrigine (Lamictal)?

Which medication increases the half-life of lamotrigine (Lamictal)? A. Topiramate (Topamax) B. Gabapentin (Neurontin) C. Oxcarbazepine (Trileptal) D. Valproic acid (Depakene) or divalproex sodium (Depakote) E. Carbamazepine (Tegretol) The answer is D. Divalproex sodium (Depakote) inhibits the glucuronidation of lamotrigine (Lamictal) and increases its half-life. The dose of lamotrigine needs to be decreased, when combined… Read More »

Which of the drugs, used to prevent migraine in adults, has been most extensively studied in children and adolescents?

Which of the following medications, used to prevent migraine headaches in adults, has been most extensively studied in children and adolescents? A. Topiramate (Topamax) B. Valproic acid (Depakene) C. Verapamil (Calan) D. Amitriptyline (Elavil) E. Fluoxetine (Prozac) The answer is A. Topiramate (Topamax) has been studied in children with pediatric migraine with or without aura,… Read More »

Pancreatitis in children has been associated with which medication used to prevent migraine headaches?

Pancreatitis in children has been associated with which medication used to prevent migraine headaches? A. Valproic acid (Depakene) or divalproex sodium (Depakote) B. Topiramate (Topamax) C. Propranolol (Inderal) D. Magnesium E. All of the above The answer is A. The most common adverse effects associated with divalproex sodium are relatively benign (weight gain, tremor, and… Read More »

Which combination of drugs has the greatest risk of serious cutaneous disorders?

Which combination of medications has the greatest risk of serious cutaneous disorders? A. Pregabalin (Lyrica) and valproic acid (Depakene) B. Divalproex sodium (Depakote) and topiramate (Topamax) C. Gabapentin (Neurontin) and lamotrigine (Lamictal) D. Divalproex sodium and lamotrigine (Lamictal) E. Zonisamide (Zonegran) and oxcarbazepine (Trileptal) The answer is D. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis… Read More »

Mood disorders: Intervention

As has been indicated, assessment of a primary mood disorder, especially depression, is difficult and involves exploration of many factors, since the mood disorder may be masked by physical problems and other mental disorders. Social workers are trained to look at all of the factors that are impinging on the individual, but they must be… Read More »

Antiepileptic Drugs

Antiepileptic drugs are a class of medications developed to treat people with seizures. Tremendous effort and resources have been dedicated to epilepsy research. In the last years new antiepileptic drugs have become available for use. Even more surprisingly, these drugs have been found to improve the lives of people with a variety of medical disorders… Read More »

Anticonvulsant Drugs

Pharmacologic Profile General Use Anticonvulsants are used to decrease the incidence and severity of seizures due various etiologies. Some anticonvulsants are used parenterally in the immediate treatment of seizures. It is not uncommon for patients to require more than one anticonvulsant to control seizures on a long-term basis. Many regimens are evaluated with serum level… Read More »