Tag Archives: Desipramine

Pharmacological Treatment of Dementia

General guidelines for psychotropic medication use in frail elderly patients are applicable. Systematic evidence to support the effectiveness of particular psychotropic drugs in dementia patients is limited. Therefore, choice of drug class may be based on clinical evidence, and choice of agent is often based on the side-effect profile and on the characteristics of a… Read More »

Pharmacotherapy of Adult ADHD

Originally conceptualized as a disorder of childhood (), attention deficit hyperactivity disorder (ADHD) is increasingly recognized in adults. attention deficit hyperactivity disorder is estimated to affect 2-9% of school-age children and up to 5% of adults (). Although some investigators question the persistence of attention deficit hyperactivity disorder in adulthood (), long-term controlled follow-up studies… Read More »

Nonstimulant medications in the treatment of adults with ADHD

Here are some important points regarding nonstimulants in the treatment of adults with ADHD. Tricyclic antidepressants and bupropion are second-line therapies. Antidepressant dosing of the agents appears necessary for attention deficit hyperactivity disorder efficacy. Serotonergic medications do not appear effective in the treatment of core attention deficit hyperactivity disorder symptoms but may be useful for… Read More »

Bipolar Depression: Antidepressants

Tricyclic Antidepressants Literature is sparse on controlled studies of tricyclic antidepressants for bipolar depression. Tricyclic antidepressants are more effective in the treatment of unipolar depression than in bipolar depression. The risk of switching patients from bipolar depression to mania and of shortening cycle lengths makes tricyclic antidepressants unattractive choices for the treatment of bipolar depression.… Read More »

What medications are used to treat ADHD in women and girls?

Research and clinical experience have shown that stimulant medications are the most effective first-line treatment for ADHD in both males and females. Currently, there are many medication formulations, including stimulants (methylphenidate and amphetamine preparations) and nonstimulants for the treatment of attention-deficit/hyperactivity disorder. Although a few skeptics continue to voice concerns over the prescription of medication… Read More »

Information about ADHD for Patients and Families

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in young and school-aged children. However, it is not merely a childhood disorder. In recent years, an increasing number of adults have been diagnosed with ADHD, raising some concern that it may be overdiagnosed. Estimates of the prevalence (i.e., percentage of the population affected) of attention-deficit/hyperactivity disorder… Read More »

Pharmacologic Treatment in Children and Adolescents for OCD

Clomipramine (Anafranil) Clomipramine (Anafranil), a tricyclic antidepressant (TCA) and potent serotonin re-uptake inhibitor, was used in the first controlled pharmacologic treatment trial in children and adolescents for OCD. Nineteen pediatric patients (mean age, 14.5 ± 2.3 years) were studied in a 12-week double-blind placebo-controlled crossover study (5 weeks of active medication) (). Doses of clomipramine… Read More »

Pharmacological Treatment of Pain

While medications are often prescribed for all types of chronic pain, research has consistently shown that several classes have proven efficacy for the treatment of neuropathic pain. Ideally, pharmacotherapy of pain would be specifically selected on the basis of considerations of etiology (e.g., ischemic, neuropathic), pathophysiology (e.g., demyelination, central pain), and anatomy (e.g., C fibers,… Read More »

Minor Depression: Tricyclic Antidepressant

Tricyclic antidepressants entered the market in the 1960s after the Monoamine Oxidase Inhibitors but quickly lost their popularity when the selective serotonin reuptake inhibitors entered the market. Although tricyclic antidepressants are as effective as the selective serotonin reuptake inhibitors and serotonin/norepinephrine reuptake inhibitors in treating most forms of depression, they have the potential for cardiotoxicity… Read More »