Tag Archives: Dibenzodiazepine

Schizophrenia: Atypical Antipsychotics

Many atypical antipsychotics are available. In addition to those reviewed in the following sections, atypical agents include perospirone (Sumitomo’s Lullan) and zotepine (Fujisawa’s Lodopin, Aventis’s Nipolept, Orion Pharma’ s Zoleptil, generics). These drugs are not discussed in detail here because their mechanisms of action are similar to those of other atypical agents, they are launched… Read More »

Drug-centred drug research

The disease-centred model of drug action has restricted our understanding of the effects of drugs used in psychiatry by directing attention to the effects of drugs on a hypothetical disease process and neglecting other areas. For example, although there is ample research about effects of the new generation of antipsychotic drugs on the numerous different… Read More »

Atypical Antipsychotics For The Treatment Of Schizophrenia

Clozapine • Clozapine was discovered in 1952, developed by Sandoz (Novartis), and introduced in Europe in 1972 • Clozapine is a dibenzodiazepine derivative that was the first of the atypical antipsychotics to be developed • It has high affinity for dopamine D4 receptor and relatively week activity at D1, D2, D3, and D5 receptors. Clozapine… Read More »