Tag Archives: Dilantin

Phenobarbital: 15 mg; 30mg ; 60mg; 100mg. Uses and Administration

Phenobarbital is a barbiturate that may be used as an antiepileptic to control partial and generalised tonic-clonic seizures. It is also used as part of the emergency management of acute seizures including status epilepticus. The dose should be adjusted to the needs of the individual patient to achieve adequate control of seizures; this usually requires… Read More »

Treatment Of The Child Or Adolescent With Newly Diagnosed Epilepsy

Paediatric epilepsy is amazingly diverse. In some children, basic diagnosis, seizure classification and treatment are straightforward. Other patients have difficult-to-diagnose seizures, complicated seizure classification and a variable response to treatment. Some seizures are subclinical, others are barely noticeable, and occasionally they are life threatening. Many children with epilepsy have no associated disabilities, but all children… Read More »

Dietary Therapies for Epilepsy in Children

For centuries, starvation and dehydration were reported to improve seizure control. In addition, substances as diverse as mistletoe, turpentine, and marijuana were claimed to be effective for epilepsy. In 1858, Sir Sieveking wrote, “There is scarcely a substance in the world, capable of passing through the gullet of man, that has not at one time… Read More »

Which drugs is most likely to lead to overt hypothyroidism?

Which medication, when given to patients with preexisting treated hypo-thyroidism, is most likely to lead to overt hypothyroidism? A. Lamotrigine (Lamictal) B. Carbamazepine (Tegretol) C. Phenytoin (Dilantin) D. Divalproex sodium (Depakote) E. Gabapentin (Neurontin) The answer is B. Enzyme-inducing antiepilepsy medications, including carbamazepine (Tegretol) and oxcarbazepine (Trileptal), can reduce serum thyroid hormone concentrations through increased… Read More »

Which drug has the greatest risk of SJS when used as monotherapy?

Which medication has the greatest risk of Stevens-Johnson syndrome (SJS) when used as monotherapy? A. Carbamazepine (Tegretol) B. Divalproex sodium (Depakote) C. Gabapentin (Neurontin) D. Topiramate (Topamax) E. Lamotrigine (Lamictal) The answer is A. Some medications used for prevention of headaches are associated with the severe cutaneous reactions, SJS and TEN. In a case control… Read More »

Which drug can increase the metabolism and decrease the efficacy of oral contraceptives?

Which medication can increase the metabolism and decrease the efficacy of oral contraceptives? A. Tegretol B. Oxcarbazepine (Trileptal) C. Phenytoin (Dilantin) D. Topiramate (Topamax) E. All of the above The answer is E. Medications with predominantly hepatic metabolism may decrease the efficacy of oral contraceptives, especially when higher-thanusual doses of the medications are combined with… Read More »

Which of the drugs is the first choice for a patient with trigeminal neuralgia?

Which of the following medications is the first choice for a patient with trigeminal neuralgia? A. Gabapentin (Neurontin) B. Phenytoin (Dilantin) C. Lioresal D. Lamotrigine (Lamictal) E. Carbamazepine (Tegretol) The answer is E. All of the medications listed are used to prevent the episodic facial pain of trigeminal neuralgia, but carbamazepine (Tegretol), at doses from… Read More »

Match the cause of episodic unilateral facial pain…

Match the cause of episodic unilateral facial pain with its most effective preventative pharmacologic therapy. Each answer may be used once, more than once, or not at all. A. Cluster headache (CH) B. Paroxysmal hemicrania (PH) C. Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) D. Trigeminal neuralgia E. Hemicrania continua 1. Lamotrigine… Read More »

Antiepileptic Drugs

Antiepileptic drugs are a class of medications developed to treat people with seizures. Tremendous effort and resources have been dedicated to epilepsy research. In the last years new antiepileptic drugs have become available for use. Even more surprisingly, these drugs have been found to improve the lives of people with a variety of medical disorders… Read More »

Anticonvulsant Drugs

Pharmacologic Profile General Use Anticonvulsants are used to decrease the incidence and severity of seizures due various etiologies. Some anticonvulsants are used parenterally in the immediate treatment of seizures. It is not uncommon for patients to require more than one anticonvulsant to control seizures on a long-term basis. Many regimens are evaluated with serum level… Read More »