Tag Archives: Felbamate

Treatment Of The Child Or Adolescent With Newly Diagnosed Epilepsy

Paediatric epilepsy is amazingly diverse. In some children, basic diagnosis, seizure classification and treatment are straightforward. Other patients have difficult-to-diagnose seizures, complicated seizure classification and a variable response to treatment. Some seizures are subclinical, others are barely noticeable, and occasionally they are life threatening. Many children with epilepsy have no associated disabilities, but all children… Read More »

Treatment of the epilepsy patient with hepatic disease

The liver is the principal organ of drug metabolism. Some drugs are absorbed from the gut, delivered to the liver and undergo first-pass metabolism prior to reaching the systemic circulation. Metabolism of these drugs is significantly affected by hepatic vascular supply; if hepatic blood flow is reduced, first-pass metabolism is decreased and more drug reaches… Read More »

Treatment of the epilepsy patient with renal disease

Seizures may occur in uraemic encephalopathy, dialysis disequilibrium syndrome and dialysis encephalopathy. In addition, renal insufficiency and dialysis may both have effects on anti-epileptic drug pharmacokinetics. Renal impairment can alter the fraction of anti-epileptic drug absorbed, volume of distribution, protein binding and renal drug clearance. Renal impairment may alter the gastric pH, cause small intestinal… Read More »

Treatment of the elderly with epilepsy

Older adults have increased steadily in number and proportion of the total world population. In the United States, the population aged 65 and older numbered 35 million in 2000 and is expected to more than double by 2050. The older population was 12% of the total population in 2000 and will increase to 20% by… Read More »

Best evidence for choosing anti-epileptic drugs in the older adult

There are few trials to support the choice of one medication for all older patients with epilepsy. However, some comparative head-to-head trials of anti-epileptic drugs in older adults have been conducted. Craig and colleagues compared valproic acid with phenytoin. A total of 166 patients over the age of 65 with adult-onset seizures were randomized to… Read More »

Second-Generation Anti-Epileptic Drugs

Drugs are listed in order of approval in the USA, from oldest to newest. Felbamate Felbamate is a broad-spectrum anti-epileptic drug. It is not considered to be a first-line drug because of its potential for serious idiosyncratic side-effects, including potentially fatal aplastic anaemia (incidence of 1 in 3000) and hepatic failure (incidence of 1 in… Read More »

Anti-Epileptic Drug Selection

Selection of anti-epileptic drugs can be very confusing. Each anti-epileptic drug has unique characteristics, including spectrum of activity, cost, pharmacokinetic and pharmacodynamic properties, likelihood for dose-related side-effects and risk of serious health risks. Therefore, to the frustration of many prescribers, there is not a ‘first choice’ selection in specific treatment situations such as initiation in… Read More »

Antiepileptic Drugs

Antiepileptic drugs are a class of medications developed to treat people with seizures. Tremendous effort and resources have been dedicated to epilepsy research. In the last years new antiepileptic drugs have become available for use. Even more surprisingly, these drugs have been found to improve the lives of people with a variety of medical disorders… Read More »

Anticonvulsant Drugs

Pharmacologic Profile General Use Anticonvulsants are used to decrease the incidence and severity of seizures due various etiologies. Some anticonvulsants are used parenterally in the immediate treatment of seizures. It is not uncommon for patients to require more than one anticonvulsant to control seizures on a long-term basis. Many regimens are evaluated with serum level… Read More »

Mood Stabilizing Medications in the Treatment of Psychotic Disorders

Mood Stabilizing Medications in the Treatment of Psychotic Disorders of Children and Adolescents, Other Treatments, and Alternative Treatments For a variety of reasons, other medications are added frequently to the psychopharmacological treatment of chronic psychotic conditions in children and adolescents. Among these, mood stabilizers (valproate, lithium, lamotrigene, and others) play a significant role in the… Read More »