Tag Archives: Guanfacine

Nonstimulant medications in the treatment of adults with ADHD

Here are some important points regarding nonstimulants in the treatment of adults with ADHD. Tricyclic antidepressants and bupropion are second-line therapies. Antidepressant dosing of the agents appears necessary for attention deficit hyperactivity disorder efficacy. Serotonergic medications do not appear effective in the treatment of core attention deficit hyperactivity disorder symptoms but may be useful for… Read More »

What medications are used to treat ADHD in women and girls?

Research and clinical experience have shown that stimulant medications are the most effective first-line treatment for ADHD in both males and females. Currently, there are many medication formulations, including stimulants (methylphenidate and amphetamine preparations) and nonstimulants for the treatment of attention-deficit/hyperactivity disorder. Although a few skeptics continue to voice concerns over the prescription of medication… Read More »

Information about ADHD for Patients and Families

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in young and school-aged children. However, it is not merely a childhood disorder. In recent years, an increasing number of adults have been diagnosed with ADHD, raising some concern that it may be overdiagnosed. Estimates of the prevalence (i.e., percentage of the population affected) of attention-deficit/hyperactivity disorder… Read More »

Chronic Illness: Current Therapies

The main goal of bipolar disorder drug treatment is to establish euthymia (stable mood with a persistent sense of well-being) without inducing mania or rapid cycling (i.e., four or more mood episodes in a 12-month period). For this reason, drug treatment usually consists of an agent or, more frequently, combinations of agents that exert both… Read More »

Specific Migraine-Preventive Agents: Other Drugs

Alpha Antagonists The U.S. Headache Consortium Guidelines and the AHCPR Technical Review included 17 controlled trials of a2 agonists for the prevention of migraine: 16 of clonidine () and one of guanfacine. The evidence from these trials suggests that a2 agonists are minimally, and not conclusively, efficacious. Of the 11 placebo-controlled trials of clonidine, 3… Read More »

TR-PTSD: Implications for Clinicians

TR-PTSD: Treatment Resistant Posttraumatic Stress Disorder While SSRIs and cognitive behavioral therapy have been deemed the prime treatment for PTSD (posttraumatic stress disorder), many do not respond. There are many different factors contributing to treatment-resistance and it varies between individuals. As such, there is limited evidence-based research on the obvious next step for treatment of… Read More »

Therapy for TR-PTSD: Anti-adrenergic Agents

Prolonged duration of adrenergic activation heightens the risk of developing PTSD (posttraumatic stress disorder). Often those with posttraumatic stress disorder have an altered regulation of their adrenergic system. Anti-adrenergic agents may therefore be able to reverse or minimize the development and/or symptoms of PTSD (posttraumatic stress disorder). The following drugs have been evaluated in relation… Read More »

Interpreting the Pharmacotherapy Literature in PTSD

The diverse presentation of symptoms in posttraumatic stress disorder and the number of neurobiological systems that may be affected present a challenge in the search for effective pharmacological agents in treatment. Very few controlled clinical studies in pharmacotherapy exist, although several medications have shown promise in both open trials and case reports. Table Controlled drug… Read More »

Review of Pharmacotherapy Literature in Posttraumatic Stress Disorder

Tricyclic Antidepressants Three placebo-controlled trials of traditional tricyclic antidepressants in chronic posttraumatic stress disorder have been published, all among male war veterans. The three drugs studied were desipramine, imipramine, and amitriptyline. The outcomes may reflect, in part, differences among these drugs and other factors such as length of trials, dosages, or symptom profiles. Desipramine was… Read More »

Treatment Of Cognitive Side Effects

Even schizophrenic patients who have scored average or above average in cognitive scores have a decrement in cognitive performance compared to their scores before the onset of their illness. The patient level of cognitive functioning might be the most important determinant of real-world outcomes. Evidence for a positive role on cognitive functioning of atypical antipsychotics… Read More »