Tag Archives: Indomethacin

Pharmacological Treatment of Dementia

General guidelines for psychotropic medication use in frail elderly patients are applicable. Systematic evidence to support the effectiveness of particular psychotropic drugs in dementia patients is limited. Therefore, choice of drug class may be based on clinical evidence, and choice of agent is often based on the side-effect profile and on the characteristics of a… Read More »

Preventive Treatment for Migraine

Migraine is a common episodic headache disorder characterized by attacks that consist of various combinations of headache and neurologie, gastrointestinal, and autonomie symptoms. It has a one-year prevalence of approximately 18% in women, 6% in men, and 4% in children. The second edition of the International Classification of Headache Disorders (ICHD-2) subclassifies migraine into migraine… Read More »

Specific Migraine-Preventive Agents: Other Drugs

Alpha Antagonists The U.S. Headache Consortium Guidelines and the AHCPR Technical Review included 17 controlled trials of a2 agonists for the prevention of migraine: 16 of clonidine () and one of guanfacine. The evidence from these trials suggests that a2 agonists are minimally, and not conclusively, efficacious. Of the 11 placebo-controlled trials of clonidine, 3… Read More »

Anti-Inflammatory Drugs

There are two classes of anti-inflammatory drugs that will be considered here. These are the non-steroidal anti-inflammatory drugs (NSAIDs) and the cyclo-oxygenase type 2 inhibitor drugs (COXIBs). Both work by reduction of prostaglandin synthesis, a marker of the inflammatory response and a potent compound in inducing sensitization of primary afferent nociceptors. They differ in the… Read More »


Headache which is not due to intracranial or systemic pathology is described as primary headache. Primary headaches are appropriately treated in the pain clinic, whereas secondary headaches require investigation. Diagnosis is made by history. Examination and investigations may be necessary to exclude secondary headache. Diagnostic criteria have been defined by the Headache Classification Committee of… Read More »

Which drug has shown benefit in treating SUNCT?

Which medication has shown benefit in treating SUNCT and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA)? A. Lamotrigine (Lamictal) B. Gabapentin (Neurontin) C. Topiramate (Topamax) D. Lidocaine E. All of the above The answer is E. SUNCT and SUNA are primary headache syndromes, classified as TACs, and associated with hypothalamic activation. They… Read More »

Which is more common in migraineurs, as compared to nonmigraineurs?

Which of the following is more common in migraineurs, as compared to nonmigraineurs? A. Elevated blood pressure response to stress B. Syncope C. Orthostatic hypotension D. Resting tachycardia E. All of the above The answer is B. A population-based study was conducted to examine the association between migraine and syncope-related autonomic nervous system symptoms. A… Read More »

The nonprescription migraine combination drugs…

The nonprescription migraine combination medication acetaminophen / aspirin /caffeine: A. Was found possibly superior to sumatriptan (Imitrex) in a head-to-head comparison in acute migraine. B. Is more likely to cause medication overuse headache (MOH) than a triptan. C. Causes a less intractable MOH than a triptan. D. Appears to be less effective than ibuprofen in… Read More »