Tag Archives: Isoniazid

Treatment of the epilepsy patient with hepatic disease

The liver is the principal organ of drug metabolism. Some drugs are absorbed from the gut, delivered to the liver and undergo first-pass metabolism prior to reaching the systemic circulation. Metabolism of these drugs is significantly affected by hepatic vascular supply; if hepatic blood flow is reduced, first-pass metabolism is decreased and more drug reaches… Read More »

Treatment for Anxiety Disorders in the Medically Ill

Treatment of anxiety disorders in the medically ill depends upon the relationship between anxiety symptoms and physical disease. Some patients have persisting symptoms or exacerbations of anxiety disorders that existed before the onset of physical disease. In that case, treatment should be similar to that given to patients without comorbid illness. Other patients, perhaps the… Read More »

Delirium: Etiology

Delirium has a wide variety of etiologies, which may occur alone or in combination (). These include primary cerebral disorders, systemic disturbances that affect cerebral function, drug and toxin exposure (including intoxication and withdrawal), and a range of factors that can contribute to delirium but have an uncertain role as etiological factors by themselves (psychological… Read More »

Neuralgia and Peripheral Neuropathy

A neuropathy refers to dysfunction in a nerve secondary to nerve damage. It can affect a single nerve (a mononeuropathy) or many nerves (a polyneuropathy). It may or may not be painful. A bilateral symmetrical neuropathy is usually of systemic cause. A painful mononeuropathy is often referred to as a neuralgia. Pathophysiology Localized or systemic… Read More »

Consequences of the disease-centred model

As preceding chapters have documented, over the 1950s and 60s views of drugs used in psychiatry changed dramatically. When they were first introduced, the neuroleptics were regarded as producing their therapeutic effects by creating a neurological disease akin to Parkinson’s disease. However within a decade, they were being presented as ‘magic bullets’ that produced improvement… Read More »

Corticosteroid Effects On Antimicrobial CSF And Bacterial Killing

Bacterial growth and death in the cerebrospinal fluid (CSF) both result in the release of proinflammatory bacterial products, such as peptidoglycan or lipopolysaccharide (LPS) that worsen central nervous system inflammation. For example, lipopolysaccharide activates Toll-like receptor 4 signaling in a wide variety of cells, ultimately leading to nuclear factor kappa B (NF-kB)-mediated transcription of proinflammatory… Read More »

Side Effects of Mood Stabilizers and Atypical Antipsychotics

This post provides an overview of developmental issues related to side effects, and then reviews the most common adverse events and concerns related to mood stabilizers and atypical antipsychotics. There are clear developmental differences in adverse event expression or side effects risks when mood stabilizers and antipsychotics are used in children and adolescents. All the… Read More »