Tag Archives: Lamotrigine

Lamotrigine: 25mg, 50mg, 100mg, 150mg, 200mg, 250mg. Uses and Administration

Lamotrigine, a phenyltriazine compound, is an antiepileptic used mainly for monotherapy or adjunctive treatment of partial seizures and primary and secondarily generalised tonic-clonic seizures. It may be used for seizures associated with the Lennox-Gastaut syndrome and for the maintenance treatment of bipolar disorder. The doses given below for the use of lamotrigine in epilepsy are… Read More »

Bipolar Depression

The notion that bipolar and unipolar depression might be distinct illnesses was first proposed in the middle of the 20th century. Before this time, manic-depressive illness was considered to encompass a broad range of psychopathology, including recurrent unipolar depression. We now recognize that there are substantial differences between depression arising from bipolar disorder and with… Read More »

Bipolar Depression: Treatment Acute Pharmacotherapy

Lithium For many years, lithium was considered to be the standard treatment for bipolar depression. Improvement rates of 80% have been reported in nine placebo-controlled studies, conducted mostly in the 1970s. Response rates for lithium were equivalent to those for tricyclic antidepressants (tricyclic antidepressants). A recent study of outpatients with bipolar depression compared the efficacy… Read More »

Bipolar Depression: Antidepressants

Tricyclic Antidepressants Literature is sparse on controlled studies of tricyclic antidepressants for bipolar depression. Tricyclic antidepressants are more effective in the treatment of unipolar depression than in bipolar depression. The risk of switching patients from bipolar depression to mania and of shortening cycle lengths makes tricyclic antidepressants unattractive choices for the treatment of bipolar depression.… Read More »

Treatment of Anxiety in the Medically Ill

Psychotherapy An overemphasis on psychopharmacology in the care of medically ill patients may result in overlooking the value of psychotherapy. The first step in the treatment of anxiety is to spend time listening to and talking with the patient. Just as in psychotherapy with any patient, empathic listening is a powerful tool to relieve distress.… Read More »

Information about Bipolar Disorder for Patients and Families

Bipolar disorder, also called manic-depressive disorder, is a recurrent illness in which the individual’s mood cycles between depression and mania with periods of normality. The illness is a mood disorder. The individual’s moods may swing from manic euphoria, with boundless energy in pursuit of grandiose plans, to depths of depression, with feelings of despair and… Read More »

Pharmacological Treatment of Pain

While medications are often prescribed for all types of chronic pain, research has consistently shown that several classes have proven efficacy for the treatment of neuropathic pain. Ideally, pharmacotherapy of pain would be specifically selected on the basis of considerations of etiology (e.g., ischemic, neuropathic), pathophysiology (e.g., demyelination, central pain), and anatomy (e.g., C fibers,… Read More »

Schizophrenia: AMPA Receptor Modulators

Glutamate modulators for the treatment of schizophrenia have generated some interest because several lines of evidence support the idea that a weakened glutamatergic tone in the brains of schizophrenics upsets a balance between glutamatergic and dopaminergic transmission. This imbalance may then predispose schizophrenics to a risk of sensory overload and exaggerated responsiveness of the monoaminergic… Read More »

Combination Therapy in Bipolar Disorder

Monotherapy for bipolar disorder is well established as both acute and prophylactic treatment, the most familiar drugs used in these roles being lithium, sodium valproate, and carbamazepine. The choice of agent can be guided at least in part by the subtype of bipolar disorder, for instance, valproate possibly being more efficacious in rapid cycling illness… Read More »

Combination Treatments In Relation To Illness Subtype And Illness Phase

The evolution of polypharmacological treatment initiated in an acute phase of illness will depend upon the context of the presentation. Use of more than one medication in a first manic presentation may arise from the need to control a combination of agitation, possible psychotic symptoms and elevated mood. Acute control of disturbed behavior is an… Read More »