Tag Archives: Lexapro

Alzheimer’s Therapy: Antidepressants

Overview. Major depression affects approximately 15% of Alzheimer’s disease patients. By comparison, 5-12% of the general population aged 15 years or older in the major pharmaceutical markets experience at least one episode of major depression per year. Because depression itself may lead to declines in cognition and function, treatment of depression in Alzheimer’s disease patients… Read More »

Minor Depression: Bupropion

Dopaminergic/Noradrenergic Agents Bupropion (GSK’s Wellbutrin/Wellbutrin XR) acts on the noradren-ergic and dopaminergic system by inhibiting reuptake of norepinephrine and dopamine. Because bupropion does not affect the serotonergic system, this drug has become a common alternative or adjunct therapy for patients unable to bear the serotonergic side effects associated with serotonin reuptake inhibition (e.g., sedation, weight… Read More »

Minor Depression: Escitalopram, Paroxetine, Sertraline, and Fluoxetine

Selective Serotonin Reuptake Inhibitors The seven available agents in the selective serotonin reuptake inhibitor class are citalopram (Lund-beck’s Cipramil, Forest Laboratories’ Celexa, generics) and its single enan-tiomer, escitalopram (Lundbeck’s Cipralex, Forest’s Lexapro); paroxetine (GSK’s Paxil/Seroxat, Novartis’s Frosinor, generics); the controlled-release version of paroxetine (GSK’s Paxil CR); sertraline (Pfizer’s Zoloft); fluoxetine (Eli Lilly’s Prozac, generics); and… Read More »

Minor Depression: Dopaminergic/Noradrenergic Agents

Dual-mechanism dopaminergic/noradrenergic antidepressants are not a popular focus of drug development programs; only a small percentage of drugs in development are based on this mechanism. These compounds offer the promise of freedom from sexual side effects (bupropion [GSK’s Wellbutrin, Wellbutrin XR] is commonly praised for its freedom from sexual side effects), but they have poor… Read More »

Chronic Illness: Current Therapies

The main goal of bipolar disorder drug treatment is to establish euthymia (stable mood with a persistent sense of well-being) without inducing mania or rapid cycling (i.e., four or more mood episodes in a 12-month period). For this reason, drug treatment usually consists of an agent or, more frequently, combinations of agents that exert both… Read More »

Escitalopram 5 mg, 10 mg, 20 mg Tablets

Escitalopram (ess-sital-o-pram) [Lexapro] Escitalopram Classification (The therapeutic classification, which categorizes drugs by the disease state they are used to treat, appears first, followed by the pharmacologic classification, which is based on the drug’s mechanism of action.) Therapeutic class: antidepressants Pharmacologic class of Escitalopram: selective serotonin reuptake inhibitors (selective serotonin reuptake inhibitors (SSRIs) Pregnancy Category (pregnancy… Read More »

Citalopram 10 mg, 20 mg, 40 mg Tablets

Citalopram (si-tal-oh-pram) [Celexa] Citalopram Classification (The therapeutic classification, which categorizes drugs by the disease state they are used to treat, appears first, followed by the pharmacologic classification, which is based on the drug’s mechanism of action.) Therapeutic class: antidepressants Pharmacologic class of Citalopram: selective serotonin reuptake inhibitors (selective serotonin reuptake inhibitors (SSRIs) Pregnancy Category (pregnancy… Read More »

When Is Treatment Finished?

After my third relapse, I agreed with my doctor that I should stay on antidepressants indefinitely. My depression is so painful and disruptive to my life that I want to do anything I can to try to prevent a recurrence. Most people with depression do get better after several months, or even sooner with effective… Read More »

Dissociative Disorders

We all experience moments of dissociation. We ask ourselves how we “got there so fast,” speak of “spacing out” or “feeling like I was watching myself as I gave my presentation,” or find ourselves daydreaming when we should have been listening. There are a range of dissociative experiences, from those experienced by everyone to severe… Read More »

Dissociative Disorders: Definitions

Dissociation is an experience, or a discernible process, in which consciousness is disrupted so that what might usually seem to be consistent, continuous, connected, and integrated is compartmentalized into autonomous groups of feelings, memories, and perceptions that may be remembered in a dreamlike, unreal, or vague state or that are repressed and out of conscious… Read More »