Tag Archives: Loxapine

Pharmacotherapy in the Treatment of People With Schizophrenia

The pharmacological agents most primarily associated with treatment of schizophrenia are grouped in a large and heterogeneous family, the antipsychotics. Recently, this family has been subdivided into the typicals, or neuroleptics, and the atypicals (see Tables Selected Typical Antipsychotic Drugs and Their Characteristics and Atypical Antipsychotics: Relative Potencies and Side Effects). The neuroleptics are so… Read More »

Adjunctive Pharmacotherapy and Related Issues

Managing antipsychotic side effects. Antipsychotic drugs produce problematic side effects in many individuals (see Table Side Effects of Typical Antipsychotic Drugs). A major category of side effects results from neurotransmitter dysregulation of the extra-pyramidal motor system. It is thought that these side effects are the result of an imbalance of dopaminergic and acetylcholinergic activity in… Read More »

Pharmacological treatment for schizophrenia

Pharmacological treatments are an essential component of a comprehensive approach to the treatment of schizophrenia. Rational pharmacotherapies can contribute greatly to symptom relief and to a broader psychosocial recovery for affected individuals. However, antipsychotic drugs do not cure schizophrenia. Moreover, if not used judiciously, drug therapies can create significant financial, side-effect, and medical morbidity burdens… Read More »

Treatment for Schizophrenia: Antipsychotic Drugs

Modern drug treatment for schizophrenia dates to the early 1950s, when Deniker and Delay reported the antipsychotic effects of chlorpromazine (). Chlorpromazine was introduced in the United States in 1954, followed over the next three decades by several drugs, including fluphenazine, haloperidol, perphenazine, and thioridazine, with similar therapeutic effects. All of these so-called first-generation antipsychotics… Read More »

Schizophrenia: Other Pharmacological Treatments

Because antipsychotic medications often fail to resolve the full range of schizophrenic psychopathology and other common symptoms (e.g., anxiety, depression, mood instability, motor unrest), adjunctive treatments are commonly tried. Adjunctive pharmacological treatments in patients with schizophrenia have been the subject of numerous reviews (). In addition, some psychotropic medications other than antipsychotics have been used… Read More »

Antipsychotic Drug Quetiapine (Seroquel)

Information About Antipsychotic Drug Quetiapine (Seroquel) for Patients and Families Quetiapine (Seroquel) is an antipsychotic drug used in the treatment of psychotic disorders, including schizophrenia, schizoaffective disorder, psychotic depression, and acute mania in bipolar disorder. Quetiapine is one of the second-generation antipsychotics, a new class of medicines that have actions different from those of older,… Read More »

Antipsychotic Drug Clozapine (Clozaril)

Information About Antipsychotic Drug Clozapine (Clozaril) for Patients and Families Clozapine (Clozaril) was used in Europe for many decades before it become available in the United States in 1989. Clozapine is one of the earlier second-generation antipsychotics that represent a new class of medicines with actions uniquely different from those of the older, first-generation antipsychotics.… Read More »

Antidepressants in the Treatment of Psychotic Depression

Since the advent of tricyclic antidepressants in the late 1950s, it has been noted that psychotic major depression responds less robustly to tricyclic antidepressants alone than does nonpsychotic major depression. Angst noted that the presence of hypochondriacal delusions in 200 patients with depression that he studied predicted poor response to open-label treatment to 200 mg/day… Read More »

Antipsychotics For The Treatment Of Schizophrenia

Following the Anatomical Therapeutic Chemical (ATC) classification system by WHO Collaborating Centre for Drug Statistics Methodology), antipsychotics (ATC N05A) are classified as: • N05AA Phenothiazines with aliphatic side-chain: Chlorpromazine, Levomepromazine, Promazine, Triflupromazine, Cyamemazine, Chlorproethazine • N05AB Phenothiazines with piperazine structure: Dixyrazine, Fluphenazine, Perphenazine, Prochlorperazine, Thiopropazate, Trifluoperazine, Acetophenazine, Thioproperazine, Butaperazine, Perazine • N05AC Phenothiazines with piperidine… Read More »

Typical Antipsychotics For The Treatment Of Schizophrenia

Lithium • Lithium and lithium salts (especially carbonate or citrate) were the focus of research in depression topic in the 1930’s. Lithium carbonate was launched in 1939 by Solvay for the treatment of depression and schizophrenia, and in 2002 Glaxo launched it for the treatment of mania • For many years, the effect of lithium… Read More »