Tag Archives: Lyrica

Treatment Of The Child Or Adolescent With Newly Diagnosed Epilepsy

Paediatric epilepsy is amazingly diverse. In some children, basic diagnosis, seizure classification and treatment are straightforward. Other patients have difficult-to-diagnose seizures, complicated seizure classification and a variable response to treatment. Some seizures are subclinical, others are barely noticeable, and occasionally they are life threatening. Many children with epilepsy have no associated disabilities, but all children… Read More »

TTHs occurring about once to twice a week…

At a new-patient appointment, a 29-year-old woman reported TTHs occurring about once to twice a week. She had multiple repetitive questions about her headaches and, despite normal brain imaging in the past year, was difficult to reassure that her headaches were not due to a dread disease. At your suggestion, she considered a preventative medication;… Read More »

Which combination of drugs has the greatest risk of serious cutaneous disorders?

Which combination of medications has the greatest risk of serious cutaneous disorders? A. Pregabalin (Lyrica) and valproic acid (Depakene) B. Divalproex sodium (Depakote) and topiramate (Topamax) C. Gabapentin (Neurontin) and lamotrigine (Lamictal) D. Divalproex sodium and lamotrigine (Lamictal) E. Zonisamide (Zonegran) and oxcarbazepine (Trileptal) The answer is D. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis… Read More »

Which drug can increase the metabolism and decrease the efficacy of oral contraceptives?

Which medication can increase the metabolism and decrease the efficacy of oral contraceptives? A. Tegretol B. Oxcarbazepine (Trileptal) C. Phenytoin (Dilantin) D. Topiramate (Topamax) E. All of the above The answer is E. Medications with predominantly hepatic metabolism may decrease the efficacy of oral contraceptives, especially when higher-thanusual doses of the medications are combined with… Read More »

Most effective in preventing attacks of short-lasting unilateral neuralgiform headache attacks…

Which of the following oral agents has been shown to be most effective in preventing attacks of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)? A. Gabapentin (Neurontin) B. Indomethacin (Indocin) C. Carbamazepine (Tegretol) D. Lamotrigine (Lamictal) E. Pregabalin (Lyrica) The answer is D. SUNCT/SUNA is particularly refractory to prevention with oral… Read More »

Which of the medications is approved by the FDA for the treatment of fibromyalgia?

Which of the following medications is approved by the U.S. Food and Drug Administration (FDA) for the treatment of fibromyalgia? A. Gabapentin (Neurontin) B. Pregabalin (Lyrica) C. Intravenous (IV) immunoglobulin D. Oxcarbazepine (Trileptal) E. Nortriptyline (Pamelor) The answer is B. Patients with fibromyalgia, who are generally middle-aged women, complain of diffuse musculoskeletal pain, sleep problems,… Read More »

Antiepileptic Drugs

Antiepileptic drugs are a class of medications developed to treat people with seizures. Tremendous effort and resources have been dedicated to epilepsy research. In the last years new antiepileptic drugs have become available for use. Even more surprisingly, these drugs have been found to improve the lives of people with a variety of medical disorders… Read More »

Anticonvulsant Drugs

Pharmacologic Profile General Use Anticonvulsants are used to decrease the incidence and severity of seizures due various etiologies. Some anticonvulsants are used parenterally in the immediate treatment of seizures. It is not uncommon for patients to require more than one anticonvulsant to control seizures on a long-term basis. Many regimens are evaluated with serum level… Read More »

Anticonvulsant Medications

Neuropathic pain is defined as pain secondary to a dysfunction of the nervous system without active ongoing neural damage. While the most common treatments for nociceptive pain include anti-inflammatory and opioid medications, anticonvulsant medications (ACMs) are the first-line drugs for neuropathic pain. Both older (conventional) and newer anticonvulsant drugs may be used in patients with… Read More »

Drugs Commonly Used Against Epilepsy

The following pages discuss the most commonly used antiepileptic drugs, listed alphabetically. A discussion of the role of benzodiazepines (clonazepam, clobazam, clorazepate, diazepam, lorazepam) follows. Acetazolamide Acetazolamide (Diamox ®) can be used with another drug to treat absence and myoclonic seizures. It is also used to treat partial or generalized seizures that occur more often… Read More »