Tag Archives: Memantine

Pharmacological Treatment of Dementia

General guidelines for psychotropic medication use in frail elderly patients are applicable. Systematic evidence to support the effectiveness of particular psychotropic drugs in dementia patients is limited. Therefore, choice of drug class may be based on clinical evidence, and choice of agent is often based on the side-effect profile and on the characteristics of a… Read More »

Alzheimer’s Disease Therapies

Current Therapies for Alzheimer’s Disease Because there is currently no cure for Alzheimer’s disease (), the primary goal of treatment remains the relief of cognitive, functional, and behavioral symptoms associated with the disease. Hence, current therapies aim to improve the quality of life for both Alzheimer’s disease patients and the caregivers who often must cope… Read More »

Alzheimer’s Therapy: N-Methyl-D-Aspartate Receptor Antagonists

Overview. A consequence of Alzheimer’s disease is neuronal loss, the result of a cascade of complex intracellular events. Excitotoxic reactions due to excessive glutamate release are thought to contribute to this neuronal cell death. Blocking glutamate receptors (NMDA receptors) is one approach to reducing cell death. In the past, however, drugs targeting NMDA receptors have… Read More »

Alzheimer’s Therapy: Acetylcholinesterase Inhibitors

Overview. Acetylcholinesterase inhibitors are the only drugs approved for the treatment of mild to moderate Alzheimer’s disease in the major markets. acetylcholinesterase inhibitors do not cure Alzheimer’s disease but do alleviate the cholinergic deficit observed in Alzheimer’s disease patients. Cognitive symptoms are occasionally improved but most often are only stabilized by the drugs (). Studies… Read More »

Pharmacological Treatment of Pain

While medications are often prescribed for all types of chronic pain, research has consistently shown that several classes have proven efficacy for the treatment of neuropathic pain. Ideally, pharmacotherapy of pain would be specifically selected on the basis of considerations of etiology (e.g., ischemic, neuropathic), pathophysiology (e.g., demyelination, central pain), and anatomy (e.g., C fibers,… Read More »

Chronic Illness: Current Therapies

The main goal of bipolar disorder drug treatment is to establish euthymia (stable mood with a persistent sense of well-being) without inducing mania or rapid cycling (i.e., four or more mood episodes in a 12-month period). For this reason, drug treatment usually consists of an agent or, more frequently, combinations of agents that exert both… Read More »

Future diagnosis and management of Alzheimer’s disease

Diagnostic Issues The diagnosis of Alzheimer’s disease is and will remain primarily clinical. Current diagnostic criteria and methods of assessment highlight the importance of a systematic history, physical and neurological examination, complemented by appropriate neuropsychological assessments, structural and functional brain imaging studies, as well as electrophysiological and biological tests. The clinical diagnosis of Alzheimer’s disease… Read More »

Assessment Of Treatment Response In Severe Dementia

The cholinesterase inhibitors donepezil, galantamine and rivastigmine enhance cholinergic neurotransmission and provide cognitive, functional and behavioural benefits in mild-to-moderate Alzheimer’s disease. Further data show donepezil to be effective in moderate-to-severe disease. Memantine, an NMDA-receptor antagonist, has been shown to be efficacious in moderate-to-severe Alzheimer’s disease and severe Alzheimer’s disease. Memantine positively influenced both cognitive and… Read More »

Beyond Cholinesterase Inhibition

The discovery that the cholinergic system is lost first and to the greatest degree in Alzheimer’s disease unleashed a course of research spanning more than two decades that has resulted in efficacious and targeted therapies for Alzheimer’s disease treatment. The compounds that provided this success were cholinesterase inhibitors but drugs acting upon other transmitter systems… Read More »