Tag Archives: Mesoridazine

Adjunctive Pharmacotherapy and Related Issues

Managing antipsychotic side effects. Antipsychotic drugs produce problematic side effects in many individuals (see Table Side Effects of Typical Antipsychotic Drugs). A major category of side effects results from neurotransmitter dysregulation of the extra-pyramidal motor system. It is thought that these side effects are the result of an imbalance of dopaminergic and acetylcholinergic activity in… Read More »

Pharmacological treatment for schizophrenia

Pharmacological treatments are an essential component of a comprehensive approach to the treatment of schizophrenia. Rational pharmacotherapies can contribute greatly to symptom relief and to a broader psychosocial recovery for affected individuals. However, antipsychotic drugs do not cure schizophrenia. Moreover, if not used judiciously, drug therapies can create significant financial, side-effect, and medical morbidity burdens… Read More »

Treatment for Schizophrenia: Antipsychotic Drugs

Modern drug treatment for schizophrenia dates to the early 1950s, when Deniker and Delay reported the antipsychotic effects of chlorpromazine (). Chlorpromazine was introduced in the United States in 1954, followed over the next three decades by several drugs, including fluphenazine, haloperidol, perphenazine, and thioridazine, with similar therapeutic effects. All of these so-called first-generation antipsychotics… Read More »

Antipsychotics For The Treatment Of Schizophrenia

Following the Anatomical Therapeutic Chemical (ATC) classification system by WHO Collaborating Centre for Drug Statistics Methodology), antipsychotics (ATC N05A) are classified as: • N05AA Phenothiazines with aliphatic side-chain: Chlorpromazine, Levomepromazine, Promazine, Triflupromazine, Cyamemazine, Chlorproethazine • N05AB Phenothiazines with piperazine structure: Dixyrazine, Fluphenazine, Perphenazine, Prochlorperazine, Thiopropazate, Trifluoperazine, Acetophenazine, Thioproperazine, Butaperazine, Perazine • N05AC Phenothiazines with piperidine… Read More »

Drugs in Treatment of Schizophrenia

  The introduction of chlorpromazine (Thorazine), the first of the antipsychotic drugs (also known as neuroleptics), in 1952 revolutionized the treatment of schizophrenia. Since then, these drugs have become the mainstay of treatment for people with schizophrenia. Before these drugs were discovered, many who suffered from this illness spent most of their lives in hospitals,… Read More »

Schizophrenia, Psychotic Disorders, and Antipsychotics

The primary indication for use of antipsychotics is the presence of psychosis in a number of conditions, including schizophrenia, schizoaffective disorder, delusional disorder, brief psychotic disorder (which maybe present in a number of personality disorders), mood disorders with psychotic features, or psychotic disturbance secondary to an underlying medical condition or substance use disorders, resulting from… Read More »

Atypical Antipsychotics

Atypical Antipsychotics: Side Effects A number of typical and atypical antipsychotics increase the QTc interval and augment the risk for torsade de pointes (torsades des pointes) and ventricular arrhythmias. Cardiovascular Risk QT relates to the time lapse from the beginning of the QRS until the end of the T-wave; this corresponds to the ventricular systole.… Read More »