Tag Archives: Naproxen

Alzheimer’s Disease Therapies

Current Therapies for Alzheimer’s Disease Because there is currently no cure for Alzheimer’s disease (), the primary goal of treatment remains the relief of cognitive, functional, and behavioral symptoms associated with the disease. Hence, current therapies aim to improve the quality of life for both Alzheimer’s disease patients and the caregivers who often must cope… Read More »

Alzheimer’s Therapy: Nonsteroidal Anti-inflammatory Drugs

Overview. Epidemiological studies have suggested that patients taking nonsteroidal anti-inflammatory drugs have a decreased risk for Alzheimer’s disease (). However, clinical trials in Alzheimer’s disease have not borne this out; in a recent study, naproxen and rofecoxib (Merck’s Vioxx) use in patients with mild to moderate Alzheimer’s disease failed to slow cognitive decline (). Naproxen… Read More »

Preventive Treatment for Migraine

Migraine is a common episodic headache disorder characterized by attacks that consist of various combinations of headache and neurologie, gastrointestinal, and autonomie symptoms. It has a one-year prevalence of approximately 18% in women, 6% in men, and 4% in children. The second edition of the International Classification of Headache Disorders (ICHD-2) subclassifies migraine into migraine… Read More »

Specific Migraine-Preventive Agents: Other Drugs

Alpha Antagonists The U.S. Headache Consortium Guidelines and the AHCPR Technical Review included 17 controlled trials of a2 agonists for the prevention of migraine: 16 of clonidine () and one of guanfacine. The evidence from these trials suggests that a2 agonists are minimally, and not conclusively, efficacious. Of the 11 placebo-controlled trials of clonidine, 3… Read More »

Specific Migraine-Preventive Agents: Serotonin Antagonists

The antiserotonin, migraine-preventive drugs are potent 5-HT2B- and 5-HT2C-receptor antagonists, whereas metachlorophenyl piperazine (mCPP), a 5-HT2B- and 5-HT2C-receptor agonist, induces migraine in susceptible individuals. Methysergide, cyproheptadine, and pizotifen, effective migraine prophylactic drugs, are 5-HT2B-and 5-HT2C-receptor antagonists, whereas ketanserin, a selective 5-HT2A- and a poor 5-HT2B- and 5-HT2C-receptor antagonist, is not. mCPP, a major metabolite of… Read More »

Anti-Inflammatory Drugs

There are two classes of anti-inflammatory drugs that will be considered here. These are the non-steroidal anti-inflammatory drugs (NSAIDs) and the cyclo-oxygenase type 2 inhibitor drugs (COXIBs). Both work by reduction of prostaglandin synthesis, a marker of the inflammatory response and a potent compound in inducing sensitization of primary afferent nociceptors. They differ in the… Read More »

Opioid Analgesics

Pharmacologic Profile General Use Management of moderate to severe pain. Fentanyl is also used as a general anesthetic adjunct. General Action and Information Opioids bind to opiate receptors in the CNS, where they act as agonists of endogenously occurring opioid peptides (eukephalins and endorphins). The result is alteration to the perception of and response to… Read More »

Disease-Modifying Therapies for Mild-To-Moderate Alzheimer’s Disease

Cholinesterase inhibitors An important aim of therapies for mild-to-moderate Alzheimer’s disease is slowing or reversing disease progression. There is only limited indirect evidence that cholinesterase inhibitors may have this effect. In an analysis of 135 matched pairs of patients, half of whom were taking cholinesterase inhibitors and half of whom were not, disease progression was… Read More »

Matching SSRI to Depressive Subtype

Atypical Depression Atypical depression is characterized by mood reactivity and two of the following: weight or appetite increase, hypersomnia, leaden paralysis and a pattern of interpersonal rejection sensitivity. MAOIs have been found to be superior to TCAs for atypical depression but recent views are that SSRIs are also an effective treatment for this subtype. Response… Read More »

Headaches

Several types of headaches are unique to sleep and its disorders. Thus, evaluation of headache should also include temporal information during the 24-hour cycle, which may offer clues to the diagnosis. Key headaches that are classically associated with sleep include cluster headaches, migraines, chronic paroxysmal hemicrania, and hypnic headaches. Additionally, sleep apnea can help trigger… Read More »