Tag Archives: Nomifensine

Drug treatment of elderly patients with depression

There is a consensus that antidepressant therapy is effective and should be recommended for the treatment of depression in the elderly. Because of the pharmacokinetic changes in the elderly, the tolerability of antidepressants, especially of the classic tricyclics, is reduced compared with younger populations. However, this problem can be managed by a careful dosing regime… Read More »

Amine uptake blocking agents

The tricyclic antidepressants (TCAs) Imipramine is a derivative of the first antipsychotic chlorpromazine. In the late 1950s it was tested in schizophrenia: it had little effect on the psychotic symptoms but was observed to elevate mood. Soon, imipramine and its close relative amitriptyline were tested in depressed patients and found to have good efficacy. In… Read More »