Tag Archives: Ofloxacin

Bacterial Meningitis: Antimicrobial Therapy

The initial management of the patient with suspected acute bacterial meningitis is empiric antimicrobial and adjunctive therapy begun immediately after obtaining blood for bacterial culture. Respiratory isolation for the first 24 hours of antimicrobial therapy is recommended only for patients with suspected meningococcal meningitis. Respiratory isolation is not required for patients with meningitis due to… Read More »

Treatment of the epilepsy patient with hepatic disease

The liver is the principal organ of drug metabolism. Some drugs are absorbed from the gut, delivered to the liver and undergo first-pass metabolism prior to reaching the systemic circulation. Metabolism of these drugs is significantly affected by hepatic vascular supply; if hepatic blood flow is reduced, first-pass metabolism is decreased and more drug reaches… Read More »

Principles of Antimicrobial Therapy

A governing principle in the treatment of infectious diseases is summarized by the aphorism “the right drug for the right bug,” a statement that is as complex as it is simple. This aphorism is particularly critical when considering infections involving the central nervous system (CNS) for two main reasons: (1) the blood-brain barrier (BBB) limits… Read More »

Pharmacodynamics Of Antimicrobial Agents In Bacterial Meningitis

Pharmacodynamics entails the interactions that occur between the antimicrobial agent and the pathogen, and, although separate from pharmacokinetic properties, is dependent on these processes with respect to localizing antimicrobials at sites of infection. There are several pharmacodynamic properties of antimicrobials relevant to bacterial meningitis, including bactericidal / bacteriostatic activity, time- versus concentration-dependent killing, and postantimicrobial… Read More »