Tag Archives: Primidone

Phenobarbital: 15 mg; 30mg ; 60mg; 100mg. Uses and Administration

Phenobarbital is a barbiturate that may be used as an antiepileptic to control partial and generalised tonic-clonic seizures. It is also used as part of the emergency management of acute seizures including status epilepticus. The dose should be adjusted to the needs of the individual patient to achieve adequate control of seizures; this usually requires… Read More »

Outgrowing Epilepsy in Children

Slightly more than half of the children who have epilepsy outgrow it. This simple and positive fact raises important questions: Which children should be treated? How much medication should they receive? How long should antiepileptic drugs be used? Doctors’ views on antiepileptic drugs have changed. Several decades ago, many doctors believed that seizures must be… Read More »

Dietary Therapies for Epilepsy in Children

For centuries, starvation and dehydration were reported to improve seizure control. In addition, substances as diverse as mistletoe, turpentine, and marijuana were claimed to be effective for epilepsy. In 1858, Sir Sieveking wrote, “There is scarcely a substance in the world, capable of passing through the gullet of man, that has not at one time… Read More »

Treatment of the epilepsy patient with cardiac disease

Atrial fibrillation (AF) occurs in 9% of patients over the age of 80 years, and prevalence is increasing as the population ages. All patients with AF should be anti-coagulated with warfarin for stroke prevention unless there is a clear contraindication. It is therefore particularly important in this patient group that seizures are well controlled, as… Read More »

Anti-Epileptic Drug Characteristics

Phenytoin Phenytoin has been used for over 50 years. Thus, the characteristics and side-effects have been well elucidated. Its primary use is for treatment of partial epilepsy, including simple and complex partial seizures, as well as generalized tonic-clonic seizures, whether of primary or partial onset. Phenytoin can be initiated with a ‘loading dose’ of 13-20… Read More »

Anti-Epileptic Drug Selection

Selection of anti-epileptic drugs can be very confusing. Each anti-epileptic drug has unique characteristics, including spectrum of activity, cost, pharmacokinetic and pharmacodynamic properties, likelihood for dose-related side-effects and risk of serious health risks. Therefore, to the frustration of many prescribers, there is not a ‘first choice’ selection in specific treatment situations such as initiation in… Read More »

Anti-Epileptic Drug Dosing Schedules

Dosing intervals that are inappropriately long can lead to problems with both tolerability, when serum concentrations are too high, and efficacy, when they are too low. This is only a problem for certain drugs, depending on whether the drug truly has a wide therapeutic window. Carbamazepine has a narrow therapeutic window because many people experience… Read More »

Antiepileptic Drugs

Antiepileptic drugs are a class of medications developed to treat people with seizures. Tremendous effort and resources have been dedicated to epilepsy research. In the last years new antiepileptic drugs have become available for use. Even more surprisingly, these drugs have been found to improve the lives of people with a variety of medical disorders… Read More »

Anticonvulsant Drugs

Pharmacologic Profile General Use Anticonvulsants are used to decrease the incidence and severity of seizures due various etiologies. Some anticonvulsants are used parenterally in the immediate treatment of seizures. It is not uncommon for patients to require more than one anticonvulsant to control seizures on a long-term basis. Many regimens are evaluated with serum level… Read More »

Mood Stabilizing Medications in the Treatment of Psychotic Disorders

Mood Stabilizing Medications in the Treatment of Psychotic Disorders of Children and Adolescents, Other Treatments, and Alternative Treatments For a variety of reasons, other medications are added frequently to the psychopharmacological treatment of chronic psychotic conditions in children and adolescents. Among these, mood stabilizers (valproate, lithium, lamotrigene, and others) play a significant role in the… Read More »