Tag Archives: Reminyl

Alzheimer’s Disease Therapies

Current Therapies for Alzheimer’s Disease Because there is currently no cure for Alzheimer’s disease (), the primary goal of treatment remains the relief of cognitive, functional, and behavioral symptoms associated with the disease. Hence, current therapies aim to improve the quality of life for both Alzheimer’s disease patients and the caregivers who often must cope… Read More »

Alzheimer’s Therapy: Acetylcholinesterase Inhibitors

Overview. Acetylcholinesterase inhibitors are the only drugs approved for the treatment of mild to moderate Alzheimer’s disease in the major markets. acetylcholinesterase inhibitors do not cure Alzheimer’s disease but do alleviate the cholinergic deficit observed in Alzheimer’s disease patients. Cognitive symptoms are occasionally improved but most often are only stabilized by the drugs (). Studies… Read More »

Alzheimer’s Therapy: Galantamine

Galantamine (Shire/Janssen’s Razadyne) () is the most recent entrant in the Alzheimer’s disease market. Galantamine was approved for the treatment of mild to moderate Alzheimer’s disease in the United States and Europe in 2001. The agent is in Phase III clinical trials in Japan. Galantamine is currently in Phase III trials in the United States… Read More »

Information about Alzheimer’s Disease for Patients and Families

Alzheimer’s disease is the most common and well-known form of degenerative dementia. By definition, dementia is a syndrome, a cluster of symptoms, of impaired memory and cognition. Dementia is a cognitive disorder that impairs an individual’s memory and ability for reasoning, awareness, and judgment. Cognitive impairment in Alzheimer’s disease may involve disturbance of language (aphasia),… Read More »

Schizophrenia: Acetylcholinesterase Inhibitors

Three acetylcholinesterase inhibitors are on the market for the treatment of Alzheimer’s disease: Japan&Japan/Shire/Janssen’s galantamine (Reminyl), Eisai/Pfizer’s donepezil (Aricept), and Novartis’s rivastigmine (Exelon/Prometax). Clinical studies evaluating these agents in the treatment of the cognitive dysfunction and negative symptoms associated with schizophrenia have been performed, but only galantamine appears to be in commercial development for schizophrenia… Read More »

Schizophrenia: Serotonin-Dopamine Antagonists

Serotonin-dopamine antagonists, together with dopamine partial agonists, are considered atypical antipsychotics. serotonin-dopamine antagonists have been used for the treatment of schizophrenia since the early 1990s, and currently marketed serotonin-dopamine antagonists include Novartis’s clozapine (Clozaril/Leponex, generics), Janssen’s risperidone (Risperdal), Eli Lilly’s olanzapine (Zyprexa), AstraZeneca’s quetiapine (Seroquel), and Pfizer’s ziprasidone (Geodon/Zeldox). TABLE . Emerging Therapies in Development… Read More »

Practical issues in using cholinesterase inhibitors

This review of published work combined with clinical experience brings out certain common characteristics among cholinesterase inhibitors: • Gastrointestinal side-effects (nausea, vomiting, diarrhoea, anorexia) are dose-related and transient, avoidable to a great extent by a slower titration up to therapeutic doses (Table Therapeutic closes of cholinesterase inhibitors in clinical use); they may be a limiting… Read More »

Symptomatic Therapy for Alzheimer’s Disease: Cholinesterase Inhibitors

Symptomatic therapy for Alzheimer’s disease has already come of age, with the availability in most countries of three cholinesterase inhibitors: donepezil (Aricept), rivastigmine (Exelon) and galantamine (Reminyl). These all produce modest improvement and stabilization in the majority of patients. A recent meta-analysis concluded that there is modest but significant therapeutic effect from all three, with… Read More »