Tag Archives: Rifampin

Bacterial Meningitis: Antimicrobial Therapy

The initial management of the patient with suspected acute bacterial meningitis is empiric antimicrobial and adjunctive therapy begun immediately after obtaining blood for bacterial culture. Respiratory isolation for the first 24 hours of antimicrobial therapy is recommended only for patients with suspected meningococcal meningitis. Respiratory isolation is not required for patients with meningitis due to… Read More »

Delirium: Etiology

Delirium has a wide variety of etiologies, which may occur alone or in combination (). These include primary cerebral disorders, systemic disturbances that affect cerebral function, drug and toxin exposure (including intoxication and withdrawal), and a range of factors that can contribute to delirium but have an uncertain role as etiological factors by themselves (psychological… Read More »

Principles of Antimicrobial Therapy

A governing principle in the treatment of infectious diseases is summarized by the aphorism “the right drug for the right bug,” a statement that is as complex as it is simple. This aphorism is particularly critical when considering infections involving the central nervous system (CNS) for two main reasons: (1) the blood-brain barrier (BBB) limits… Read More »

Corticosteroid Effects On Antimicrobial CSF And Bacterial Killing

Bacterial growth and death in the cerebrospinal fluid (CSF) both result in the release of proinflammatory bacterial products, such as peptidoglycan or lipopolysaccharide (LPS) that worsen central nervous system inflammation. For example, lipopolysaccharide activates Toll-like receptor 4 signaling in a wide variety of cells, ultimately leading to nuclear factor kappa B (NF-kB)-mediated transcription of proinflammatory… Read More »