Tag Archives: Selegiline

Pharmacological Treatment of Dementia

General guidelines for psychotropic medication use in frail elderly patients are applicable. Systematic evidence to support the effectiveness of particular psychotropic drugs in dementia patients is limited. Therefore, choice of drug class may be based on clinical evidence, and choice of agent is often based on the side-effect profile and on the characteristics of a… Read More »

Alzheimer’s Therapy: Natural Antioxidants

Overview. Natural antioxidants exhibit a degree of neuroprotection by neutralizing reactive oxygen species (ROS) that accumulate in the brain as a result of age and perhaps as the result of amyloid plaque formation. Unlike acetylcholinesterase inhibitors, which target the symptoms of Alzheimer’s disease as the disease progresses, antioxidants may act in a preventive fashion by… Read More »

Pharmacotherapy of Adult ADHD

Originally conceptualized as a disorder of childhood (), attention deficit hyperactivity disorder (ADHD) is increasingly recognized in adults. attention deficit hyperactivity disorder is estimated to affect 2-9% of school-age children and up to 5% of adults (). Although some investigators question the persistence of attention deficit hyperactivity disorder in adulthood (), long-term controlled follow-up studies… Read More »

Minor Depression

Etiology and Pathophysiology Minor depression is only a proposed diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and there are no International Classification of Diseases codes to categorize it. The proposed diagnostic category for minor depression in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition describes a depressive disorder that… Read More »

Sleep and Sleep Disorders in Noncardiopulmonary Medical Disorders

Sleep disruption is a common symptom of many medical disorders, and sleep disorders are diagnosable in almost all medical subspecialties. Sometimes sleep disorders are a consequence of medical pathophysiology, and sometimes they are a cause or precursor of that pathophysiology. This chapter reviews the relationship between sleep disorders and a variety of relatively common neurological… Read More »

Altering amyloid

amyloid precursor protein is cleaved by at least three secretase activities. Sequential cleavage by β-secretase followed by γ-secretase generates the amyloid moiety whereas cleavage by α-secretase cuts amyloid precursor protein within the amyloid sequence. Each of these enzymes then becomes a target for disease-modifying therapy. Inhibition of β-secretase or γ-secretase would be protective as would… Read More »

Possible disease-modification strategies from epidemiology

Limiting inflammation It is a curious observation that at the same time that molecular biologists were demonstrating that the immune response generated by amyloid injection may be therapeutic (), epidemiologists were showing that anti-inflammatory drugs were protective (). These observations were first made in case-control studies that showed that those receiving non-steroidal anti-inflammatory drugs (NSAIDs)… Read More »

Disease-modification trial designs

Molecular biology and epidemiology are generating targets for disease modification. But how are attempts to hit these targets be assessed? For a disease that in which the person deteriorates relentlessly, to distinguish between symptomatic treatment and disease modification is not simple. The first steps in attempts at modification of Alzheimer’s disease progression, and the scientific… Read More »

Pharmacotherapy of Treatment of Depression in Late Life

Antidepressant pharmacotherapy has become the cornerstone of management of depression in late life. Evidence from a number of meta-analyses documents convincingly that antidepressant medications are effective treatments of late-life depression. The newer medications were found to be as effective as tricyclic antidepressants () in these analyses, and generally are associated with fewer discontinuations due to… Read More »

Syndol Caplets

Paracetamol 450mg Codeine Phosphate 10mg Doxylamine Succinate 5mg Caffeine 30mg What Are These Tablets Used For? Syndol is used for the short term treatment of acute moderate pain which is not relieved by paracetamol, ibuprofen and aspirin alone such as headache, including muscle contraction or tension headache, migraine, neuralgia, period pain, toothache and other dental… Read More »