Tag Archives: Sumatriptan

Preventive Treatment for Migraine

Migraine is a common episodic headache disorder characterized by attacks that consist of various combinations of headache and neurologie, gastrointestinal, and autonomie symptoms. It has a one-year prevalence of approximately 18% in women, 6% in men, and 4% in children. The second edition of the International Classification of Headache Disorders (ICHD-2) subclassifies migraine into migraine… Read More »

Escitalopram 5 mg, 10 mg, 20 mg Tablets

Escitalopram (ess-sital-o-pram) [Lexapro] Escitalopram Classification (The therapeutic classification, which categorizes drugs by the disease state they are used to treat, appears first, followed by the pharmacologic classification, which is based on the drug’s mechanism of action.) Therapeutic class: antidepressants Pharmacologic class of Escitalopram: selective serotonin reuptake inhibitors (selective serotonin reuptake inhibitors (SSRIs) Pregnancy Category (pregnancy… Read More »

Headache

Headache which is not due to intracranial or systemic pathology is described as primary headache. Primary headaches are appropriately treated in the pain clinic, whereas secondary headaches require investigation. Diagnosis is made by history. Examination and investigations may be necessary to exclude secondary headache. Diagnostic criteria have been defined by the Headache Classification Committee of… Read More »

Migraine

Migraine is a primary headache. Diagnosis can be made from the history. However, investigation may be required to exclude headache of other aetiology. Pathophysiology There are vascular and neural hypotheses. The ophthalmic division of the trigeminal nerve supplies painful structures within the head. Stimulation of the trigeminal ganglion releases a peptide from trigeminal neurones which… Read More »

Intravenous magnesium

Intravenous magnesium: A. Is poorly tolerated in the treatment of acute migraine. B. Has been shown to inhibit central sensitization with acute migraine. C. Shows preferential benefit with migraine with aura as compared to migraine without aura. D. Is effective in migraine based on an antiserotonergic mechanism. E. All of the above The answer is… Read More »

Which drugs effective in the acute treatment of CH, but not in migraine?

Which of the following has been shown to be effective in the acute treatment of CH, but not in migraine? A. Serotonin receptor agonists B. Calcitonin gene-related peptide (CGRP) receptor antagonists C. Somatostatin receptor agonists D. Nitric oxide synthase (NOS) blockers E. Adenosine A: receptor agonists The answer is C. The subcutaneous somatostatin receptor agonist,… Read More »

Which of the triptans is available in more than one drug delivery formulation?

Which of the triptans listed is available in more than one medication delivery formulation? A. Almotriptan (Axert) B. Rizatriptan (Maxalt) C. Frovatriptan (Frova) D. Naratriptan (Amerge) E. Eletriptan (Relpax) The answer is B. Multiple formulations are currently available for sumatriptan (Imitrex; subcutaneous injection, swallowed tablet, intranasal spray), zolmitriptan (Zomig; swallowed tablet, orally dissolving tablet, intranasal… Read More »

Supplementation may improve pediatric and adolescent migraine?

Supplementation with which of the following may improve pediatric and adolescent migraine? A. Choline B. Coenzyme Q10 C. Magnesium D. Selenium None of the above The answer is B. Coenzyme Q10 (CoQ10) deficiency and response to supplementation were evaluated in pediatric and adolescent patients with migraine, with indication of beneficial effect of supplementation. A third… Read More »

Which of the triptans to have the lowest incidence of chest discomfort?

Which of the following triptans appears to have the lowest incidence of chest discomfort? A. Almotriptan (Axert) B. Subcutaneous sumatriptan (Imitrex) C. Intranasal zolmitriptan (Zomig) D. Oral sumatriptan (Imitrex) E. Eletriptan (Relpax) The answer is A. Chest discomfort, presumably related to pulmonary vasoconstriction and/or esophageal spasm, is lowest in oral triptan formulations. The tolerability of… Read More »

Risk of which is not increased in patients with migraine headaches?

Risk of which of the following is not increased in patients with migraine headaches? A. Arterial dissection B. Subarachnoid hemorrhage (SAH) C. Ischemic stroke D. Myocardial infarct (MI) E. All of the above The answer is B. An association exists between migraine and ischemic cardiovascular and cerebrovascular events, but migraine is not a risk factor… Read More »