Tag Archives: Wellbutrin

Nonstimulant medications in the treatment of adults with ADHD

Here are some important points regarding nonstimulants in the treatment of adults with ADHD. Tricyclic antidepressants and bupropion are second-line therapies. Antidepressant dosing of the agents appears necessary for attention deficit hyperactivity disorder efficacy. Serotonergic medications do not appear effective in the treatment of core attention deficit hyperactivity disorder symptoms but may be useful for… Read More »

What medications are used to treat ADHD in women and girls?

Research and clinical experience have shown that stimulant medications are the most effective first-line treatment for ADHD in both males and females. Currently, there are many medication formulations, including stimulants (methylphenidate and amphetamine preparations) and nonstimulants for the treatment of attention-deficit/hyperactivity disorder. Although a few skeptics continue to voice concerns over the prescription of medication… Read More »

Combining of two psychotropic agents

Question. My question involves the combining of two psychotropic agents. I am unclear why it is done and why it works. I treat chronically ill patients, mostly with schizophrenia or schizoaffective disorder. They are treated with agents that functionally decrease dopamine, i.e. Haldol, Clozaril etc. If they become depressed, and the depression does not respond… Read More »

Information about ADHD for Patients and Families

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in young and school-aged children. However, it is not merely a childhood disorder. In recent years, an increasing number of adults have been diagnosed with ADHD, raising some concern that it may be overdiagnosed. Estimates of the prevalence (i.e., percentage of the population affected) of attention-deficit/hyperactivity disorder… Read More »

Minor Depression: Bupropion

Dopaminergic/Noradrenergic Agents Bupropion (GSK’s Wellbutrin/Wellbutrin XR) acts on the noradren-ergic and dopaminergic system by inhibiting reuptake of norepinephrine and dopamine. Because bupropion does not affect the serotonergic system, this drug has become a common alternative or adjunct therapy for patients unable to bear the serotonergic side effects associated with serotonin reuptake inhibition (e.g., sedation, weight… Read More »

Minor Depression: Escitalopram, Paroxetine, Sertraline, and Fluoxetine

Selective Serotonin Reuptake Inhibitors The seven available agents in the selective serotonin reuptake inhibitor class are citalopram (Lund-beck’s Cipramil, Forest Laboratories’ Celexa, generics) and its single enan-tiomer, escitalopram (Lundbeck’s Cipralex, Forest’s Lexapro); paroxetine (GSK’s Paxil/Seroxat, Novartis’s Frosinor, generics); the controlled-release version of paroxetine (GSK’s Paxil CR); sertraline (Pfizer’s Zoloft); fluoxetine (Eli Lilly’s Prozac, generics); and… Read More »

Minor Depression: Triple Reuptake Inhibitors

A novel mechanism for the treatment of depression that has attracted much attention is triple reuptake inhibition. Given their additional mechanism of action on dopamine, the triple reuptake inhibitors pose a potential threat to the clinical use and commercial fortunes of selective serotonin reuptake inhibitors and serotonin/norepinephrine reuptake inhibitors. Agents of this type are being… Read More »

Minor Depression: Dopaminergic/Noradrenergic Agents

Dual-mechanism dopaminergic/noradrenergic antidepressants are not a popular focus of drug development programs; only a small percentage of drugs in development are based on this mechanism. These compounds offer the promise of freedom from sexual side effects (bupropion [GSK’s Wellbutrin, Wellbutrin XR] is commonly praised for its freedom from sexual side effects), but they have poor… Read More »

Chronic Illness: Current Therapies

The main goal of bipolar disorder drug treatment is to establish euthymia (stable mood with a persistent sense of well-being) without inducing mania or rapid cycling (i.e., four or more mood episodes in a 12-month period). For this reason, drug treatment usually consists of an agent or, more frequently, combinations of agents that exert both… Read More »