Tag Archives: Zuclopenthixol

Schizophrenia: Current Therapies

Etiology and Pathophysiology Schizophrenia has varied and ominous symptoms that generally begin in late adolescence or early adulthood and usually continue throughout life. The diagnostic criteria for schizophrenia have evolved over the past 20 years based on the different iterations of the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases.… Read More »

Drug Treatment Of Mania

When assessing the patient, enquiries should be made about their recent compliance with medication, as sudden discontinuation of lithium may have triggered the manic episode. It is usually prudent to cease any antidepressant medication they may have been taking. A physical examination and tests of the blood and urine should, if possible, precede drug treatment… Read More »

Matching SSRI to Depressive Subtype

Atypical Depression Atypical depression is characterized by mood reactivity and two of the following: weight or appetite increase, hypersomnia, leaden paralysis and a pattern of interpersonal rejection sensitivity. MAOIs have been found to be superior to TCAs for atypical depression but recent views are that SSRIs are also an effective treatment for this subtype. Response… Read More »

Antipsychotics For The Treatment Of Schizophrenia

Following the Anatomical Therapeutic Chemical (ATC) classification system by WHO Collaborating Centre for Drug Statistics Methodology), antipsychotics (ATC N05A) are classified as: • N05AA Phenothiazines with aliphatic side-chain: Chlorpromazine, Levomepromazine, Promazine, Triflupromazine, Cyamemazine, Chlorproethazine • N05AB Phenothiazines with piperazine structure: Dixyrazine, Fluphenazine, Perphenazine, Prochlorperazine, Thiopropazate, Trifluoperazine, Acetophenazine, Thioproperazine, Butaperazine, Perazine • N05AC Phenothiazines with piperidine… Read More »

Typical Antipsychotics For The Treatment Of Schizophrenia

Lithium • Lithium and lithium salts (especially carbonate or citrate) were the focus of research in depression topic in the 1930’s. Lithium carbonate was launched in 1939 by Solvay for the treatment of depression and schizophrenia, and in 2002 Glaxo launched it for the treatment of mania • For many years, the effect of lithium… Read More »